DBCO-(PEG2-VC-PAB-MMAE)2

Name: DBCO-(PEG2-VC-PAB-MMAE)2
Brand: MedChemExpress
SKU: HY-126690
Rating: 4.5 (0 reviews)

Cat. No.: HY-126690 Pureté: 99.55%: Fiche technique
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DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate. DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

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DBCO-(PEG2-VC-PAB-MMAE)2 Chemical Structure

CAS No. : 2259318-55-1

Size	Stock	Quantité
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtenir un devis
500 mg	Obtenir un devis

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Recommandations en vedette

•Related Small Molecules:

•Related Proteins:

Voir tous les produits spécifiques à Isoform Drug-Linker Conjugates for ADC:

Voir toutes les isoformes

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

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Description

DBCO-(PEG2-VC-PAB-MMAE)2 is made by MMAE conjugated to the cleavable DBCO-(PEG2-VC-PAB)2 linker. Monomethyl auristatin E (MMAE), a potent tubulin inhibitor, is a toxin payload in antibody agent conjugate^[1]. DBCO-(PEG2-VC-PAB-MMAE)2 is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

IC₅₀ & Target^[1]

Dual payloads

Auristatin

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Masse moléculaire

2835.50

Formule

C₁₄₉H₂₂₄N₂₂O₃₂

CAS No.

2259318-55-1

Appearance

Solid

Color

White to light yellow

SMILES

O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@@]([C@@H](C)CC)([H])N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCOCCOCCN(CCOCCOCCC(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=O)C(NC4=CC=C(COC(N(C)[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N(C)[C@]([C@@H](C)CC)([H])[C@H](OC)CC(N5[C@](CCC5)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C6=CC=CC=C6)O)=O)=O)=O)=O)=O)C=C4)=O)=O)=O)C(CCC(N7C8=CC=CC=C8C#CC9=CC=CC=C9C7)=O)=O)=O)=O)=O)=O)=O)=O

Livraison

Room temperature in continental US; may vary elsewhere.

Stockage

Powder	-20°C	3 years

*The compound is unstable in solutions, freshly prepared is recommended.

Solvant et solubilité

In Vitro:

DMSO : 100 mg/mL (35.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3527 mL	1.7634 mL	3.5267 mL
5 mM	0.0705 mL	0.3527 mL	0.7053 mL
10 mM	0.0353 mL	0.1763 mL	0.3527 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Calculateur de molarité
Calculateur de dilution

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Pureté et documentation

Purity: 99.55%

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Fiche technique (281 KB) SDS (252 KB)

COA (263 KB) HNMR (424 KB) RP-HPLC (254 KB) MS (69 KB)

Instruction de manipulation (2659 KB)

Références

[1]. Brian Lannutti, et al. Ror1 antibody immunoconjugates. WO2018237335A1.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.3527 mL	1.7634 mL	3.5267 mL	8.8168 mL
	5 mM	0.0705 mL	0.3527 mL	0.7053 mL	1.7634 mL
	10 mM	0.0353 mL	0.1763 mL	0.3527 mL	0.8817 mL
	15 mM	0.0235 mL	0.1176 mL	0.2351 mL	0.5878 mL
	20 mM	0.0176 mL	0.0882 mL	0.1763 mL	0.4408 mL
	25 mM	0.0141 mL	0.0705 mL	0.1411 mL	0.3527 mL
	30 mM	0.0118 mL	0.0588 mL	0.1176 mL	0.2939 mL