2. Protein Tyrosine Kinase/RTK
  3. Discoidin Domain Receptor
  4. DDR1/2 IN-4

DDR1/2 IN-4 (Compound 37) is a selective dual DDR1 and DDR2 kinase inhibitor, with a pKi of 8.6 for DDR1 and a pKi of 8.2 for DDR2. DDR1/2 IN-4 functionally inhibits the kinase activities of DDR1 and DDR2. DDR1/2 IN-4 inhibits the release of MCP-1. DDR1/2 IN-4 can be used in studies related to idiopathic pulmonary fibrosis.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

DDR1/2 IN-4

DDR1/2 IN-4 構造式

CAS 番号 : 3027967-95-6

容量 在庫状況
50 mg   お問い合わせ  
100 mg   お問い合わせ  
250 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

DDR1/2 IN-4 関連抗体

Top Publications Citing Use of Products

Discoidin Domain Receptor アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
DDR1 DDR2

  • 生物活性

  • 純度とドキュメンテーション

  • 参考文献

  • カスタマーレビュー

製品説明

DDR1/2 IN-4 (Compound 37) is a selective dual DDR1 and DDR2 kinase inhibitor, with a pKi of 8.6 for DDR1 and a pKi of 8.2 for DDR2. DDR1/2 IN-4 functionally inhibits the kinase activities of DDR1 and DDR2. DDR1/2 IN-4 inhibits the release of MCP-1. DDR1/2 IN-4 can be used in studies related to idiopathic pulmonary fibrosis[1].

IC50 & Target[1]

DDR1

8.6 (pKi)

DDR2

8.2 (pKi)

体外実験

DDR1/2 IN-4 potently binds to DDR1 (pKi=8.6) and DDR2 (pKi=8.2)[1].
DDR1/2 IN-4 potently inhibits DDR1 activity in U2OS cells, with a pIC50 of 8.0[1].
DDR1/2 IN-4 (1-30 μM; 48 h) shows no cytotoxicity against A549 cells at concentrations up to 10 μM, and only exhibits mild cytotoxicity after 48 h treatment at 30 μM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

DDR1/2 IN-4 関連抗体

Cell Viability Assay[1]

Cell Line: A549 cells
Concentration: 1-30 μM
Incubation Time: 48 h
Result: Showed no cytotoxicity at concentrations up to 10 μM; reduced cell viability to 84.9% at 30 μM.
Parmacokinetics
Species Dose Route Cmax Tmax (Plasma) T1/2 AUClast
Mice[1] 1 mg/kg i.n. 117 (plasma) ng/g 0.083 (plasma) h 2 (plasma) h 141 (plasma) ng·h/mL
体内実験

DDR1/2 IN-4 (0.1-1 mg/kg; intranasal; single administration) significantly reduces collagen-induced pulmonary MCP-1 levels by 39% in male C57BL/6N mice, confirming its in vivo activity of inhibiting DDR-mediated signaling pathways[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6N (male)[1]
Dosage: 0.1 mg/kg; 0.3 mg/kg; 1 mg/kg
Administration: intranasal; single dose
Result: Showed dose-dependent inhibition of pulmonary MCP-1 levels.
Caused a significant 39% reduction in pulmonary MCP-1 levels compared to the vehicle-treated, collagen-challenged group (p < 0.05) at 1 mg/kg.
分子量

467.45

分子式

C23H20F3N7O
CAS 番号
SMILES

O=C(NC1=CC(C(F)(F)F)=CN=C1)C2=CC=C(C)C(NC3CN(C4=C5C=NC=CN5N=C4)C3)=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

DDR1/2 IN-4 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DDR1/2 IN-43027967-95-6Discoidin Domain ReceptorABL1 kinaseDDR1idiopathic pulmonary fibrosishERG-HEK cellsC57BL/6N miceDDR2A549 cellscollagen-induced mouse modelmiceU2OS cellsInhibitorinhibitorinhibit

最近チェックした製品:

オンラインお問い合わせ

Your information is safe with us. * Required Fields.

製品名

  

カスタマ需要量 *

お名前 *

 

タイトル

メールアドレス *

 

電話番号 *

デパートメント

 

組纖名 *

市区町村

都道府県

国或いは地域 *

      

必ず会社名を記載ください。個人への返信は行いません。

備考

バルクお問い合わせ

Inquiry Information

製品名:
DDR1/2 IN-4
製品番号:
HY-181839
数量:
MCE 日本正規代理店:

カスタマーレビュー

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

製品名

  

Lot #

お名前 *

 

メールアドレス *

電話番号 *

 

部門 *

組纖名 *

 

国或いは地域 *

備考

Request for HNMR Report

We have received your request and will respond to you as soon as possible.