Delta (Phospho) Sleep Inducing Peptide  (Synonyms: DSIP-P)

Delta (Phospho) Sleep Inducing Peptide (DSIP-P) is a long-lasting sleep-promoting peptide. Delta (Phospho) Sleep Inducing Peptide induces changes in the circadian locomotor behavior in rats^[1][2][3].

Delta (Phospho) Sleep Inducing Peptide (20-300 nM) increases rat pineal N-acetyltransferase (NAT) activity induced by norepinephrine in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Delta (Phospho) Sleep Inducing Peptide (0.1 nmol/kg; i.v.; once daily for 4 times) induces changes in the circadian locomotor behavior^[1].
Delta (Phospho) Sleep Inducing Peptide (20 or 200 pmol/kg; inject into the 3rd cerebroventricle of male rats immediately before the onset of the dark period) increases slow-wave sleep and paradoxical sleep during the subsequent dark period without shortening sleep latency at a dose of 200 pmol/kg^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

928.79

C₃₅H₄₉N₁₀O₁₈P

70754-23-3

Solid

White to off-white

Trp-Ala-Gly-Gly-Asp-Ala-{Ser(PO3H2)}-Gly-Glu

WAGGDA-{Ser(PO3H2)}-GE

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

• [1]. Graf M, et al. Effects of repeated DSIP and DSIP-P administration on the circadian locomotor activity of rats. Pharmacol Biochem Behav. 1981 Nov;15(5):717-21.  [Content Brief]

  [2]. Nakagaki K, et al. Sleep-promoting effect following intracerebroventricular injection of a phosphorylated analogue of delta sleep-inducing peptide (DSIP-P) in rats. Neurosci Lett. 1988 Aug 31;91(2):160-4.  [Content Brief]

  [3]. Graf MV, Schoenenberger GA. Delta sleep-inducing peptide modulates the stimulation of rat pineal N-acetyltransferase activity by involving the alpha 1-adrenergic receptor. J Neurochem. 1987 Apr;48(4):1252-7.  [Content Brief]