2. Cell Cycle/DNA Damage
  3. Eukaryotic Initiation Factor (eIF)
  4. eIF4A-IN-3

eIF4A-IN-3, Silvestrol (HY-13251) analogue, is an eIF4A inhibitor. eIF4A-IN-3 blocks protein translation initiation by interfering with eIF4F complex assembly, preferentially inhibiting translation of mRNAs with long, highly structured 5'-untranslated regions. eIF4A-IN-3 inhibits proliferation of human breast cancer cells. eIF4A-IN-3 has moderate apical to basolateral permeability in intestinal cell monolayers and a low efflux ratio.

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eIF4A-IN-3

eIF4A-IN-3 화학구조

CAS No. : 1402931-85-4

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg   견적 받기  
10 mg   견적 받기  

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eIF4A-IN-3 Related Antibodies

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제품 설명

eIF4A-IN-3, Silvestrol (HY-13251) analogue, is an eIF4A inhibitor. eIF4A-IN-3 blocks protein translation initiation by interfering with eIF4F complex assembly, preferentially inhibiting translation of mRNAs with long, highly structured 5'-untranslated regions. eIF4A-IN-3 inhibits proliferation of human breast cancer cells. eIF4A-IN-3 has moderate apical to basolateral permeability in intestinal cell monolayers and a low efflux ratio[1].

IC50 & Target[1]

eIF4A

 

Cellular Effect
Cell Line Type Value Description References
MDA-MB-231 EC50
0.4 1
Compound: 75
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
[PMID: 23025805]
MDA-MB-231 EC50
0.4 1
Compound: 75
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
[PMID: 23025805]
MDA-MB-231 EC50
0.6 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
0.4 1
Compound: 75
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
Growth inhibition of human MDA-MB-231 cells incubated for 72 hrs by MTS assay
[PMID: 23025805]
MDA-MB-231 EC50
0.6 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
15 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
15 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
0.6 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with c-myc- 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
MDA-MB-231 EC50
15 1
Compound: 75
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
Inhibition of eIF4FA in human MDA-MB-231 cells transfected with tubulin 5'-UTR-luciferase construct assessed as reduction in translation initiation incubated for 24 hrs by differential translation assay
[PMID: 23025805]
In Vitro

eIF4A-IN-3 (Compound 75) (24 h) potently inhibits translation initiation of mRNAs with highly structured 5′UTRs in MDA-MB-231 human breast cancer cells, with a myc-LUC EC50 of 0.6 nM and tub-LUC EC50 of 15 nM[1].
eIF4A-IN-3 (72 h) potently inhibits the proliferation of MDA-MB-231 human breast cancer cells, with a growth inhibition EC50 of 0.4 nM[1].
eIF4A-IN-3 has moderate permeability across Caco-2 cell monolayers (15.5 × 10-6 cm/s) and a low efflux ratio of 2.0, indicating minimal interaction with P-glycoprotein[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

eIF4A-IN-3 Related Antibodies
분자량

509.98

화학식

C28H28ClNO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

COC1=CC=C([C@@]23OC4=CC(Cl)=CC(OC)=C4[C@]2(O)[C@@H]([C@@H]([C@H]3C5=CC=CC=C5)C(N(C)C)=O)O)C=C1
선적

Room temperature in continental US; may vary elsewhere.
보관

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

순도&문서
References
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eIF4A-IN-3 Related Classifications

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  • 농도 희석 계산기

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

eIF4A-IN-31402931-85-4Eukaryotic Initiation Factor (eIF)intestinal cell monolayerseIF4F complex5'-untranslated regionsMDA-MB-231protein translation initiationhuman breast cancer cellsP-glycoproteinmRNAsCaco-2 cell monolayerseIF4AInhibitorinhibitorinhibit

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상품명:
eIF4A-IN-3
Cat. No.:
HY-148447
수량:
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