Ferrous bisglycinate

Name: Ferrous bisglycinate
Brand: MedChemExpress
SKU: HY-130078
Rating: 4.5 (0 reviews)

Cat. No.: HY-130078 Purity: 98%: Data Sheet
COA

SDS
Handling Instructions
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Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia.

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Ferrous bisglycinate 화학구조

CAS No. : 20150-34-9

사이즈	재고	수량
500 mg	해외재고보유	Estimated Time of Arrival: December 31
1 g	해외재고보유	Estimated Time of Arrival: December 31
5 g	해외재고보유	Estimated Time of Arrival: December 31
10 g	해외재고보유	Estimated Time of Arrival: December 31
25 g	해외재고보유	Estimated Time of Arrival: December 31
50 g	해외재고보유	Estimated Time of Arrival: December 31
100 g	해외재고보유	Estimated Time of Arrival: December 31
> 100 g	견적 받기

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* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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Biological Activity
순도&문서
References
고객리뷰

제품 설명

Ferrous bisglycinate is an orally active iron fortificants and therapeutic iron supplements. Ferrous bisglycinate can be used for the research of iron deficiency anemia^[1]^[2].

In Vitro

Ferrous bisglycinate (25-200 μM; 2 h) does not affect the Caco-2 cells viability^[2].
Ferrous bisglycinate (25 μM; 2 h) increases ferritin content in the Caco-2 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	Caco-2 cells
Concentration:	0, 25, 50, 100, 200 μM
Incubation Time:	2 hours
Result:	Did not affect the viability of wild-type and divalent metal transporter 1 (DMT1) knockout Caco-2 cells.

Western Blot Analysis^[2]

Cell Line:	Caco-2 cells
Concentration:	25 μM
Incubation Time:	2 hours
Result:	Increased ferritin content and decreased DMT1 expression levels significantly in the wild-type cells.

In Vivo

Ferrous bisglycinate (500 mg/kg iron; p.o.) exerts a protective effect on colitis in mice^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Female C57BL/6 mice are induced colitis by dextran sodium sulfate (DSS)^[3]
Dosage:	500 mg/kg iron
Administration:	P.o. (add to the diet) for 10 days
Result:	Had the best survival rates (100%). Caused the least body lost (9% body loss).

Clinical Trial

분자량

203.96

화학식

C₄H₈FeN₂O₄

CAS No.

20150-34-9

Appearance

Solid

Color

Brown to breen

SMILES

O=C1[O-][Fe+2]2([O-]C(CN2)=O)NC1

선적

Room temperature in continental US; may vary elsewhere.

보관

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

용액&용해도

In Vitro:

0.1 M HCl : 2 mg/mL (9.81 mM; ultrasonic and warming and adjust pH to 2 with HCl and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.9029 mL	24.5146 mL	49.0292 mL
5 mM	0.9806 mL	4.9029 mL	9.8058 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

몰농도 계산기
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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 2 mg/mL (9.81 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

순도&문서

Purity: 98%

Select Batch:

Data Sheet (277 KB) SDS (393 KB)

COA (251 KB)

Handling Instructions (2659 KB)

References

[1]. Ferrari P, et, al. Treatment of mild non-chemotherapy-induced iron deficiency anemia in cancer patients: comparison between oral ferrous bisglycinate chelate and ferrous sulfate. Biomed Pharmacother. 2012 Sep; 66(6): 414-8. [Content Brief]

[2]. Yu X, et, al. Iron Transport from Ferrous Bisglycinate and Ferrous Sulfate in DMT1-Knockout Human Intestinal Caco-2 Cells. Nutrients. 2019 Feb 26; 11(3): 485. [Content Brief]

[3]. Constante M, et, al. Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfate-induced Colitis. Inflamm Bowel Dis. 2017 May; 23(5): 753-766. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

0.1 M HCl	1 mM	4.9029 mL	24.5146 mL	49.0292 mL	122.5730 mL
0.1 M HCl	5 mM	0.9806 mL	4.9029 mL	9.8058 mL	24.5146 mL