2. Induced Disease Models Products Metabolic Enzyme/Protease
  3. Immunology and Inflammatory Disease Models Glucose-6-Phosphate Isomerase (GPI)
  4. Arthritis Models
  5. G6PI 325-339 (human) hydrochloride

G6PI 325-339 (human) hydrochloride  (Synonyms: hG6PI (325-339) hydrochloride)

Cat. No.: HY-P10109A
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G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

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G6PI 325-339 (human) hydrochloride

G6PI 325-339 (human) hydrochloride Estructura química

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Descripciòn

G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms[1].

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

G6PI can be used to induce arthritis models.

Induction of Arthritis[2]
Background
G6PI is capable of producing antibodies in the body that induce arthritis by inducing immunoactive cells to produce cytokines (such as TNF-α, IL-1β).
Specific Modeling Methods
Mice: DAB/1 • 6-10 week old
Administration: 50 μg in complete Freund's adjuvant • s.c. at the base of the tail • single dose
Note
(1) DBA/1 mice were bred and maintained under specific-pathogen free conditions in our animal facility.
(2) Mice were sacrificed on day 12 after immunization and single-cell suspensions from draining lymph nodes were prepared.
Modeling Indicators
Morphology: Showed a strong synovialitis and inflammation of the adjacent skeletal muscle , which was dominated by neutrophilic granulocytes as a sign of acute inflammation and exhibited activation of synovial fibroblasts to a lesser extent. The synovial tissue was enlarged due to the dense inflammatory infiltrate; however, bone destruction was onlyfocally observed.
Molecular changes: Increased the levels of IL-17, TNFα, RANKL, and IFNγ.
Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Peso molecular

1801.12 (free base)

Fòrmula

C82H118ClN19O21S3.xHCl
Sequence

Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu
Sequence Shortening

IWYINCFGCETHAML
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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G6PI 325-339 (human) hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G6PI 325-339 (human)hG6PI (325-339)Glucose-6-Phosphate Isomerase (GPI)Glucose-6-Phosphate IsomeraseGPI/G6PIArthritisB10.Q miceTh1Th17G6PI proteinB cellInhibitorinhibitorinhibit

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Nombre del producto:
G6PI 325-339 (human) hydrochloride
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HY-P10109A
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