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  4. G6PI 325-339 (human)

G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

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G6PI 325-339 (human) Chemical Structure

G6PI 325-339 (human) Chemical Structure

CAS No. : 1174631-35-6

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Description

G6PI 325-339 (human) is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms[1].

In Vivo

Induction of Arthritis[2]
Background
G6PI is capable of producing antibodies in the body that induce arthritis by inducing immunoactive cells to produce cytokines (such as TNF-α, IL-1β).
Specific Modeling Methods
Mice: DAB/1 • 6-10 week old
Administration: 50 μg in complete Freund's adjuvant • s.c. at the base of the tail • single dose
Note
(1) DBA/1 mice were bred and maintained under specific-pathogen free conditions in our animal facility.
(2) Mice were sacrificed on day 12 after immunization and single-cell suspensions from draining lymph nodes were prepared.
Modeling Indicators
Morphology: Showed a strong synovialitis and inflammation of the adjacent skeletal muscle , which was dominated by neutrophilic granulocytes as a sign of acute inflammation and exhibited activation of synovial fibroblasts to a lesser extent. The synovial tissue was enlarged due to the dense inflammatory infiltrate; however, bone destruction was onlyfocally observed.
Molecular changes: Increased the levels of IL-17, TNFα, RANKL, and IFNγ.
Correlated Product(s) Complete Freund's adjuvant (CFA) (HY-153808)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

1801.12

Formula

C82H117N19O21S3

CAS No.
Sequence

Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu

Sequence Shortening

IWYINCFGCETHAML

SMILES

OC(C=C1)=CC=C1C[C@@H](C(N[C@@H]([C@@H](C)CC)C(N[C@@H](CC(N)=O)C(N[C@@H](CS)C(N[C@H](C(NCC(N[C@@H](CS)C(N[C@@H](CCC(O)=O)C(N[C@@H]([C@H](O)C)C(N[C@H](C(N[C@@H](C)C(N[C@@H](CCSC)C(N[C@H](C(O)=O)CC(C)C)=O)=O)=O)CC2=CN=CN2)=O)=O)=O)=O)=O)CC3=CC=CC=C3)=O)=O)=O)=O)NC([C@@H](NC([C@@H](N)[C@@H](C)CC)=O)CC4=CNC5=CC=CC=C45)=O

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
G6PI 325-339 (human)
Cat. No.:
HY-P10109
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