G6PI 325-339 (human) (hydrochloride) (Synonyms: hG6PI (325-339) (hydrochloride))

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G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

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G6PI 325-339 (human) (hydrochloride) Chemical Structure

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Description	G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms^[1].
Molecular Weight	1801.12 (free base)
Formula	C₈₂H₁₁₈ClN₁₉O₂₁S₃.xHCl
Sequence	Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu
Sequence Shortening	IWYINCFGCETHAML
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (267 KB) Handling Instructions (2659 KB)
References	[1]. Angela Pizzolla, et al. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Am J Pathol. 2013 Oct;183(4):1144-1155. [Content Brief] [2]. Bruns L, et al. Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther. 2009;11(4):R117. [Content Brief]

G6PI 325-339 (human) (hydrochloride) Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

G6PI 325-339 (human) (hydrochloride)hG6PI (325-339) (hydrochloride)OthersArthritisB10.Q miceTh1Th17G6PI proteinB cellInhibitorinhibitorinhibit

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G6PI 325-339 (human) (hydrochloride) (Synonyms: hG6PI (325-339) (hydrochloride))

Other Forms of G6PI 325-339 (human) (hydrochloride):

G6PI 325-339 (human) (hydrochloride) Related Antibodies

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•Related Small Molecules:

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Biological Activity

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