country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-P10109A

Copy Link Print Information

G6PI 325-339 (human) hydrochloride

Name: G6PI 325-339 (human) hydrochloride
Brand: MedChemExpress
SKU: HY-P10109A
Availability: PreOrder

(Synonyms: hG6PI (325-339) hydrochloride)

G6PI 325-339 (human) hydrochloride is an efficient inducer of arthritis in B10.Q mice. G6PI 325-339 (human) hydrochloride primes Th1 and Th17 cells cross-reacted with the murine G6PI protein. G6PI 325-339 (human) hydrochloride induces arthritis model operating through a T and B cell-dependent pathway but without antibody effector mechanisms.

For research use only. We do not sell to patients.

Formula: C₈₂H₁₁₈ClN₁₉O₂₁S₃.xHCl
Molecular Weight:1801.12 (free base)

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

G6PI 325-339 (human) hydrochloride Chemical Structure

Size

Price

Stock

Quantity

Amount: USD 0.00

* Please select Quantity before adding items.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Induced Disease Models
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Induced Disease Models

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

G6PI can be used to induce arthritis models.

Induction of Arthritis^[2]

Background

G6PI is capable of producing antibodies in the body that induce arthritis by inducing immunoactive cells to produce cytokines (such as TNF-α, IL-1β).

Specific Modeling Methods

Mice: DAB/1 • 6-10 week old
Administration: 50 μg in complete Freund's adjuvant • s.c. at the base of the tail • single dose

Note

(1) DBA/1 mice were bred and maintained under specific-pathogen free conditions in our animal facility.
(2) Mice were sacrificed on day 12 after immunization and single-cell suspensions from draining lymph nodes were prepared.

Modeling Indicators

Morphology: Showed a strong synovialitis and inflammation of the adjacent skeletal muscle , which was dominated by neutrophilic granulocytes as a sign of acute inflammation and exhibited activation of synovial fibroblasts to a lesser extent. The synovial tissue was enlarged due to the dense inflammatory infiltrate; however, bone destruction was onlyfocally observed.
Molecular changes: Increased the levels of IL-17, TNFα, RANKL, and IFNγ.

Correlated Product(s): Complete Freund's adjuvant (CFA) (HY-153808)

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Molecular Weight 1801.12 (free base)
Formula C₈₂H₁₁₈ClN₁₉O₂₁S₃.xHCl
Synonyms

hG6PI (325-339) hydrochloride
Sequence

Ile-Trp-Tyr-Ile-Asn-Cys-Phe-Gly-Cys-Glu-Thr-His-Ala-Met-Leu
Sequence Shortening

IWYINCFGCETHAML
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Angela Pizzolla, et al. A glucose-6-phosphate isomerase peptide induces T and B cell-dependent chronic arthritis in C57BL/10 mice: arthritis without reactive oxygen species and complement. Am J Pathol. 2013 Oct;183(4):1144-1155. [Content Brief]

[2]. Bruns L, et al. Immunization with an immunodominant self-peptide derived from glucose-6-phosphate isomerase induces arthritis in DBA/1 mice. Arthritis Res Ther. 2009;11(4):R117. [Content Brief]

Calculators

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Get Quote In-stock

Other size

Get Quote