2. Gene
  3. CDC37 - cell division cycle 37, HSP90 cochaperone Gene

CDC37 - cell division cycle 37, HSP90 cochaperone Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P50CDC37

Gene ID: 11140 | Gene type: protein coding

About CDC37

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,391,133-10,403,542 (from NCBI)

This gene has 10 transcripts (splice variants), 241 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to CDC 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with HSP90 and a variety of protein kinases including CDK4, CDK6, Src, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases. [provided by RefSeq, Jul 2008]

CDC37 Products(1)

mRNA Protein Name
NM_007065.4 NP_008996.1 hsp90 co-chaperone Cdc37

CDC37 Protein Structure

CDC37_N

CDC37_N: Cdc37 N terminal kinase binding (1 - 75)

CDC37_N

CDC37_N: Cdc37 N terminal kinase binding (77 - 127)

CDC37_M

CDC37_M: Cdc37 Hsp90 binding domain (135 - 282)

CDC37_C

CDC37_C: Cdc37 C terminal domain (286 - 357)

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  • 378 a.a.
Protein Preferred Names Protein Names

hsp90 co-chaperone Cdc37

CDC37 (cell division cycle 37, S. cerevisiae, homolog)

Recombinant CDC37 Proteins

Cat. No. Product Name Accession Purity
HY-P75364 CDC37 Protein, Human (sf9, GST) Q16543 (M1-V378) ≥95%

Related Diseases

Diseases Alias
Macular Degeneration, Age-Related, 15

Age Related Macular Degeneration 15

ARMD15

Macular Degeneration, Age-Related, 15, Susceptibility To

Macular Degeneration, Age-Related, Type 15
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-N1986 Cucurbitacin D 99.91% Unkown
HY-139301 DDO-5936 Inhibitor 99.20% Unkown
HY-N3417 Kongensin A ≥98.0% Unkown
HY-119906 Conglobatin / Unkown
HY-144650 Hsp90-Cdc37-IN-3 98.09% Unkown
HY-111414 Hsp90-Cdc37-IN-1 Inhibitor 99.66% Unkown
HY-RS02297 CDC37 Human Pre-designed siRNA Set A / Unkown
HY-RS02298 CDC37L1 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CDC37 VGNC VGNC:38994
Rattus norvegicus CDC37 RGD RGD:71006
Bos taurus CDC37 VGNC VGNC:106679
Mus musculus CDC37 MGD MGI:109531
Macaca mulatta CDC37 VGNC VGNC:108494
Others CDC37 NCBI