CDC37 - cell division cycle 37, HSP90 cochaperone Gene

Also Known as P50CDC37

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 11140

About CDC37

Cytogenetic location: 19p13.2 Genomic coordinates (GRCh38): 19:10,391,133-10,403,542 (from NCBI)

This gene has 10 transcripts (splice variants), 241 orthologues and 1 paralogue. Ubiquitous expression in fat (RPKM 70.6), spleen (RPKM 61.9) and 25 other tissues.

Summary

The protein encoded by this gene is highly similar to CDC 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with HSP90 and a variety of protein kinases including CDK4, CDK6, Src, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases. [provided by RefSeq, Jul 2008]

CDC37 Products (1)

mRNA	Protein	Name
NM_007065.4	NP_008996.1	hsp90 co-chaperone Cdc37

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	9660753	GOA
enables kinase binding	IPI IPI: Inferred from physical interaction	21855797	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9150368	GOA
enables scaffold protein binding	IPI IPI: Inferred from physical interaction	10409742	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within regulation of type I interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16280321	GOA
acts upstream of or within regulation of type II interferon-mediated signaling pathway	IMP IMP: Inferred from mutant phenotype	16280321	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of HSP90-CDC37 chaperone complex	IDA IDA: Inferred from direct assay	21855797	GOA
part of protein folding chaperone complex	IDA IDA: Inferred from direct assay	29127155	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDC37 Protein Structure

CDC37_N

CDC37_M

CDC37_C

0
100
200
300
378 a.a.

Protein Preferred Names	Protein Names
hsp90 co-chaperone Cdc37	CDC37 (cell division cycle 37, S. cerevisiae, homolog)

CDC37 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDC37	Q16543	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NECAB2	Homo sapiens	Q7Z6G3-2	Validated Y2H	32296183
Intra	CDC37	Q16543	NECAB2	Homo sapiens	Q7Z6G3-2	Y2H Array	32296183
Intra	CDC37	Q16543	FAM9B	Homo sapiens	Q8IZU0	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	FAM9B	Homo sapiens	Q8IZU0	Validated Y2H	32296183
Intra	CDC37	Q16543	FAM9B	Homo sapiens	Q8IZU0	Y2H Array	32296183
Intra	CDC37	Q16543	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CCHCR1	Homo sapiens	Q8TD31-3	Validated Y2H	32296183
Intra	CDC37	Q16543	CCHCR1	Homo sapiens	Q8TD31-3	Y2H Array	32296183
Intra	CDC37	Q16543	BEND7	Homo sapiens	Q8N7W2-2	Y2H Array	32296183
Intra	CDC37	Q16543	BEND7	Homo sapiens	Q8N7W2-2	Validated Y2H	32296183
Intra	CDC37	Q16543	BEND7	Homo sapiens	Q8N7W2-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NRIP3	Homo sapiens	Q9NQ35	Validated Y2H	32296183
Intra	CDC37	Q16543	NRIP3	Homo sapiens	Q9NQ35	Y2H Array	32296183
Intra	CDC37	Q16543	NRIP3	Homo sapiens	Q9NQ35	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NT5C1A	Homo sapiens	Q9BXI3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NT5C1A	Homo sapiens	Q9BXI3	Validated Y2H	32296183
Intra	CDC37	Q16543	NT5C1A	Homo sapiens	Q9BXI3	Y2H Array	32296183
Intra	CDC37	Q16543	FKBP4	Homo sapiens	Q02790	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	CDK15	Homo sapiens	Q96Q40	Lumier	25036637
Intra	CDC37	Q16543	GAS8	Homo sapiens	O95995	Y2H Array	32296183
Intra	CDC37	Q16543	GAS8	Homo sapiens	O95995	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CCDC138	Homo sapiens	Q96M89-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CCDC138	Homo sapiens	Q96M89-2	Validated Y2H	32296183
Intra	CDC37	Q16543	CCDC138	Homo sapiens	Q96M89-2	Y2H Array	32296183
Intra	CDC37	Q16543	GPRASP3	Homo sapiens	Q6PI77	Validated Y2H	32296183
Intra	CDC37	Q16543	GPRASP3	Homo sapiens	Q6PI77	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GPRASP3	Homo sapiens	Q6PI77	Y2H Array	32296183
Intra	CDC37	Q16543	CAMK2B	Homo sapiens	Q13554-3	Y2H Array	32296183
Intra	CDC37	Q16543	CAMK2B	Homo sapiens	Q13554-3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PDE9A	Homo sapiens	O76083-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PDE9A	Homo sapiens	O76083-2	Y2H Array	32296183
Intra	CDC37	Q16543	CBY2	Homo sapiens	Q8NA61-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CBY2	Homo sapiens	Q8NA61-2	Validated Y2H	32296183
Intra	CDC37	Q16543	CBY2	Homo sapiens	Q8NA61-2	Y2H Array	32296183
Intra	CDC37	Q16543	CARD9	Homo sapiens	Q9H257-2	Y2H Array	32296183
Intra	CDC37	Q16543	CARD9	Homo sapiens	Q9H257-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CARD9	Homo sapiens	Q9H257-2	Validated Y2H	32296183
Intra	CDC37	Q16543	GAS7	Homo sapiens	O60861-1	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GAS7	Homo sapiens	O60861-1	Y2H Array	32296183
Intra	CDC37	Q16543	CTAG1A	Homo sapiens	P78358	Y2H Array	32296183
Intra	CDC37	Q16543	CTAG1A	Homo sapiens	P78358	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NECAB1	Homo sapiens	Q8N987	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	NECAB1	Homo sapiens	Q8N987	Validated Y2H	32296183
Intra	CDC37	Q16543	NECAB1	Homo sapiens	Q8N987	Y2H Array	32296183
Intra	CDC37	Q16543	SYCE2	Homo sapiens	Q6PIF2	Y2H Array	32296183
Intra	CDC37	Q16543	SYCE2	Homo sapiens	Q6PIF2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	SYCE2	Homo sapiens	Q6PIF2	Validated Y2H	32296183
Intra	CDC37	Q16543	ZNF837	Homo sapiens	Q96EG3	Y2H Array	32296183
Intra	CDC37	Q16543	ZNF837	Homo sapiens	Q96EG3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZNF837	Homo sapiens	Q96EG3	Validated Y2H	32296183
Intra	CDC37	Q16543	DISC1	Homo sapiens	Q9NRI5-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	DISC1	Homo sapiens	Q9NRI5-2	Y2H Array	32296183
Intra	CDC37	Q16543	DISC1	Homo sapiens	Q9NRI5-2	Validated Y2H	32296183
Intra	CDC37	Q16543	CCDC91	Homo sapiens	Q7Z6B0-2	Validated Y2H	32296183
Intra	CDC37	Q16543	CCDC91	Homo sapiens	Q7Z6B0-2	Y2H Array	32296183
Intra	CDC37	Q16543	CCDC91	Homo sapiens	Q7Z6B0-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CAMK2G	Homo sapiens	Q13555-5	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CAMK2G	Homo sapiens	Q13555-5	Y2H Array	32296183
Intra	CDC37	Q16543	POU6F2	Homo sapiens	P78424	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	POU6F2	Homo sapiens	P78424	Y2H Array	32296183
Intra	CDC37	Q16543	CT45A1	Homo sapiens	Q5HYN5	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CT45A1	Homo sapiens	Q5HYN5	Validated Y2H	32296183
Intra	CDC37	Q16543	CT45A1	Homo sapiens	Q5HYN5	Y2H Array	32296183
Intra	CDC37	Q16543	LZTS1	Homo sapiens	Q9Y250	Validated Y2H	32296183
Intra	CDC37	Q16543	LZTS1	Homo sapiens	Q9Y250	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	LZTS1	Homo sapiens	Q9Y250	Y2H Array	32296183
Intra	CDC37	Q16543	APOE	Homo sapiens	P02649	Anti Bait CoIP	21163940
Intra	CDC37	Q16543	PRR20D	Homo sapiens	P86480	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PRR20D	Homo sapiens	P86480	Y2H Array	32296183
Intra	CDC37	Q16543	STK32A	Homo sapiens	Q8WU08-2	Validated Y2H	32296183
Intra	CDC37	Q16543	STK32A	Homo sapiens	Q8WU08-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	STK32A	Homo sapiens	Q8WU08-2	Y2H Array	32296183
Intra	CDC37	Q16543	TCF4	Homo sapiens	P15884-3	Y2H Array	32296183
Intra	CDC37	Q16543	TCF4	Homo sapiens	P15884-3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ROPN1	Homo sapiens	Q9HAT0	Validated Y2H	32296183
Intra	CDC37	Q16543	ROPN1	Homo sapiens	Q9HAT0	Y2H Array	32296183
Intra	CDC37	Q16543	ROPN1	Homo sapiens	Q9HAT0	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	FER	Homo sapiens	P16591	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	FER	Homo sapiens	P16591	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	CDK9	Homo sapiens	P50750	TAP	24189400
Intra	CDC37	Q16543	CDK9	Homo sapiens	P50750	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	ULK3	Homo sapiens	Q6PHR2	Lumier	25036637
Intra	CDC37	Q16543	CAMK2A	Homo sapiens	Q9UQM7	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CAMK2A	Homo sapiens	Q9UQM7	Validated Y2H	32296183
Intra	CDC37	Q16543	CAMK2A	Homo sapiens	Q9UQM7	Y2H Array	32296183
Intra	CDC37	Q16543	LIMK2	Homo sapiens	P53671	Lumier	25036637
Intra	CDC37	Q16543	NOS3	Homo sapiens	P29474	Anti Bait CoIP	21163940
Intra	CDC37	Q16543	NOS3	Homo sapiens	P29474	Pull Down	21163940
Intra	CDC37	Q16543	NOS3	Homo sapiens	P29474	Y2H Array	21163940
Intra	CDC37	Q16543	REEP6	Homo sapiens	Q96HR9-2	Y2H Array	32296183
Intra	CDC37	Q16543	REEP6	Homo sapiens	Q96HR9-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	REEP6	Homo sapiens	Q96HR9-2	Validated Y2H	32296183
Intra	CDC37	Q16543	PIBF1	Homo sapiens	Q4G0R1	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PIBF1	Homo sapiens	Q4G0R1	Validated Y2H	32296183
Intra	CDC37	Q16543	PIBF1	Homo sapiens	Q4G0R1	Y2H Array	32296183
Intra	CDC37	Q16543	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	KIFC3	Homo sapiens	Q9BVG8-5	Validated Y2H	32296183
Intra	CDC37	Q16543	KIFC3	Homo sapiens	Q9BVG8-5	Y2H Array	32296183
Intra	CDC37	Q16543	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	RABGEF1	Homo sapiens	Q9UJ41-4	Y2H Array	32296183
Intra	CDC37	Q16543	RABGEF1	Homo sapiens	Q9UJ41-4	Validated Y2H	32296183
Intra	CDC37	Q16543	PRMT1	Homo sapiens	Q99873-3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PRMT1	Homo sapiens	Q99873-3	Validated Y2H	32296183
Intra	CDC37	Q16543	PRMT1	Homo sapiens	Q99873-3	Y2H Array	32296183
Intra	CDC37	Q16543	JRK	Homo sapiens	O75564-2	Y2H Array	32296183
Intra	CDC37	Q16543	JRK	Homo sapiens	O75564-2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MOS	Homo sapiens	P00540	Lumier	25036637
Intra	CDC37	Q16543	CCDC152	Homo sapiens	Q4G0S7	Validated Y2H	32296183
Intra	CDC37	Q16543	CCDC152	Homo sapiens	Q4G0S7	Y2H Array	32296183
Intra	CDC37	Q16543	CCDC152	Homo sapiens	Q4G0S7	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TRIM54	Homo sapiens	Q9BYV2	Y2H Array	32296183
Intra	CDC37	Q16543	TRIM54	Homo sapiens	Q9BYV2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TRIM54	Homo sapiens	Q9BYV2	Validated Y2H	32296183
Intra	CDC37	Q16543	MID1	Homo sapiens	O15344	Y2H Array	32296183
Intra	CDC37	Q16543	MID1	Homo sapiens	O15344	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TNFAIP1	Homo sapiens	Q13829	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TNFAIP1	Homo sapiens	Q13829	Y2H Array	32296183
Intra	CDC37	Q16543	SSNA1	Homo sapiens	O43805	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	SSNA1	Homo sapiens	O43805	Y2H Array	32296183
Intra	CDC37	Q16543	BLZF1	Homo sapiens	Q9H2G9	Validated Y2H	32296183
Intra	CDC37	Q16543	BLZF1	Homo sapiens	Q9H2G9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	BLZF1	Homo sapiens	Q9H2G9	Y2H Array	32296183
Intra	CDC37	Q16543	GMCL1	Homo sapiens	Q96IK5	Y2H Array	32296183
Intra	CDC37	Q16543	GMCL1	Homo sapiens	Q96IK5	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GMCL1	Homo sapiens	Q96IK5	Validated Y2H	32296183
Intra	CDC37	Q16543	MIPOL1	Homo sapiens	Q8TD10	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MIPOL1	Homo sapiens	Q8TD10	Validated Y2H	32296183
Intra	CDC37	Q16543	MIPOL1	Homo sapiens	Q8TD10	Y2H Array	32296183
Intra	CDC37	Q16543	CAVIN1	Homo sapiens	Q6NZI2	Y2H Array	32296183
Intra	CDC37	Q16543	CAVIN1	Homo sapiens	Q6NZI2	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CAVIN1	Homo sapiens	Q6NZI2	Validated Y2H	32296183
Intra	CDC37	Q16543	PRKAR1B	Homo sapiens	P31321	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PRKAR1B	Homo sapiens	P31321	Y2H Array	32296183
Intra	CDC37	Q16543	LMNB2	Homo sapiens	Q03252	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	LMNB2	Homo sapiens	Q03252	Y2H Array	32296183
Intra	CDC37	Q16543	GRAMD2B	Homo sapiens	Q96HH9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GRAMD2B	Homo sapiens	Q96HH9	Validated Y2H	32296183
Intra	CDC37	Q16543	GRAMD2B	Homo sapiens	Q96HH9	Y2H Array	32296183
Intra	CDC37	Q16543	KRT75	Homo sapiens	O95678	Y2H Array	32296183
Intra	CDC37	Q16543	KRT75	Homo sapiens	O95678	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	KRT76	Homo sapiens	Q01546	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	KRT76	Homo sapiens	Q01546	Y2H Array	32296183
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	Anti Bait CoIP	21871133
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	GMS	27339980
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	3D-EM	27339980
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	TAP	24189400
Intra	CDC37	Q16543	CDK4	Homo sapiens	P11802	Y2H	9150368
Intra	CDC37	Q16543	CDK6	Homo sapiens	Q00534	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	HSP90AA1	Homo sapiens	P07900	Anti Bait CoIP	21871133
Intra	CDC37	Q16543	HSP90AA1	Homo sapiens	P07900	CoIP	12176997
Intra	CDC37	Q16543	HSP90AA1	Homo sapiens	P07900	TAP	24189400
Intra	CDC37	Q16543	HSP90AA1	Homo sapiens	P07900	Lumier	25036637
Intra	CDC37	Q16543	HSP90AA1	Homo sapiens	P07900	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	AKT1	Homo sapiens	P31749	CoIP	12176997
Intra	CDC37	Q16543	AKT3	Homo sapiens	Q9Y243	Lumier	25036637
Intra	CDC37	Q16543	AKT3	Homo sapiens	Q9Y243	CoIP	12176997
Intra	CDC37	Q16543	PSEN1	Homo sapiens	P49768	Anti Bait CoIP	21163940
Intra	CDC37	Q16543	PSEN1	Homo sapiens	P49768	Y2H Array	21163940
Intra	CDC37	Q16543	EGFR	Homo sapiens	P00533	TAP	24189400
Intra	CDC37	Q16543	EGFR	Homo sapiens	P00533	Lumier	25036637
Intra	CDC37	Q16543	PNMA2	Homo sapiens	Q9UL42	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PNMA2	Homo sapiens	Q9UL42	Validated Y2H	32296183
Intra	CDC37	Q16543	PNMA2	Homo sapiens	Q9UL42	Y2H Array	32296183
Intra	CDC37	Q16543	STK11	Homo sapiens	Q15831	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	SQSTM1	Homo sapiens	Q13501	TAP	24189400
Intra	CDC37	Q16543	SQSTM1	Homo sapiens	Q13501	Y2H Array	32296183
Intra	CDC37	Q16543	SQSTM1	Homo sapiens	Q13501	Y2H	21900206
Intra	CDC37	Q16543	SQSTM1	Homo sapiens	Q13501	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	IKBKE	Homo sapiens	Q14164	Anti Bait CoIP	17353931
Intra	CDC37	Q16543	IKBKE	Homo sapiens	Q14164	TAP	14743216
Intra	CDC37	Q16543	BTBD3	Homo sapiens	Q9Y2F9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	BTBD3	Homo sapiens	Q9Y2F9	Validated Y2H	32296183
Intra	CDC37	Q16543	BTBD3	Homo sapiens	Q9Y2F9	Y2H Array	32296183
Intra	CDC37	Q16543	FGFR3	Homo sapiens	P22607	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	PRMT5	Homo sapiens	O14744	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PRMT5	Homo sapiens	O14744	Y2H Array	32296183
Intra	CDC37	Q16543	ACTG1	Homo sapiens	P63261	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ACTG1	Homo sapiens	P63261	Y2H Array	32296183
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	3D-EM	27339980
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	22939624
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	GMS	27339980
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	TAP	24189400
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	Anti Tag CoIP	26496610
Intra	CDC37	Q16543	HSP90AB1	Homo sapiens	P08238	Anti Bait CoIP	11036079
Intra	CDC37	Q16543	ACTB	Homo sapiens	P60709	Y2H Array	32296183
Intra	CDC37	Q16543	ACTB	Homo sapiens	P60709	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TRAF2	Homo sapiens	Q12933	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TRAF2	Homo sapiens	Q12933	Y2H Array	32296183
Intra	CDC37	Q16543	DNAJB1	Homo sapiens	P25685	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	TRAF3	Homo sapiens	Q13114	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	TRAF3	Homo sapiens	Q13114	Y2H Array	32296183
Intra	CDC37	Q16543	PSMC6	Homo sapiens	P62333	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PSMC6	Homo sapiens	P62333	Y2H Array	32296183
Intra	CDC37	Q16543	TNIP1	Homo sapiens	Q15025	Y2H Array	32296183
Intra	CDC37	Q16543	TNIP1	Homo sapiens	Q15025	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MAP3K14	Homo sapiens	Q99558	TAP	14743216
Intra	CDC37	Q16543	MAP3K7	Homo sapiens	O43318	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	MAP3K7	Homo sapiens	O43318-2	TAP	14743216
Intra	CDC37	Q16543	RAF1	Homo sapiens	P04049	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	RAF1	Homo sapiens	P04049	Lumier	25036637
Intra	CDC37	Q16543	RAF1	Homo sapiens	P04049	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	RAF1	Homo sapiens	P04049	TAP	24189400
Intra	CDC37	Q16543	CARD10	Homo sapiens	Q9BWT7	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CARD10	Homo sapiens	Q9BWT7	Validated Y2H	32296183
Intra	CDC37	Q16543	CARD10	Homo sapiens	Q9BWT7	Y2H Array	32296183
Intra	CDC37	Q16543	SRRM4	Homo sapiens	A7MD48	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	SRRM4	Homo sapiens	A7MD48	Y2H Array	32296183
Intra	CDC37	Q16543	ZBTB26	Homo sapiens	Q9HCK0	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZBTB26	Homo sapiens	Q9HCK0	Validated Y2H	32296183
Intra	CDC37	Q16543	ZBTB26	Homo sapiens	Q9HCK0	Y2H Array	32296183
Intra	CDC37	Q16543	KCTD9	Homo sapiens	Q7L273	Y2H Array	32296183
Intra	CDC37	Q16543	KCTD9	Homo sapiens	Q7L273	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	KCTD9	Homo sapiens	Q7L273	Validated Y2H	32296183
Intra	CDC37	Q16543	CUL4B	Homo sapiens	Q13620	Lumier	25036637
Intra	CDC37	Q16543	FYN	Homo sapiens	P06241	Lumier	25036637
Intra	CDC37	Q16543	YES1	Homo sapiens	P07947	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	YES1	Homo sapiens	P07947	Lumier	25036637
Intra	CDC37	Q16543	TRAF5	Homo sapiens	O00463	Y2H Array	32296183
Intra	CDC37	Q16543	TRAF5	Homo sapiens	O00463	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	22612223
Intra	CDC37	Q16543	LRRK2	Homo sapiens	Q5S007	Anti Tag CoIP	18367605
Intra	CDC37	Q16543	LRRK2	Homo sapiens	Q5S007	TAP	16321986
Intra	CDC37	Q16543	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Array	32296183
Intra	CDC37	Q16543	GOLGA6L9	Homo sapiens	A6NEM1	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GOLGA2	Homo sapiens	Q08379	Y2H Array	32296183
Intra	CDC37	Q16543	GOLGA2	Homo sapiens	Q08379	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	SRC	Homo sapiens	P12931	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	ZNF655	Homo sapiens	Q8N720	Validated Y2H	32296183
Intra	CDC37	Q16543	ZNF655	Homo sapiens	Q8N720	Y2H Array	32296183
Intra	CDC37	Q16543	ZNF655	Homo sapiens	Q8N720	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ERBB2	Homo sapiens	P04626	Lumier	25036637
Intra	CDC37	Q16543	ERBB2	Homo sapiens	P04626	TAP	24189400
Intra	CDC37	Q16543	MUSK	Homo sapiens	O15146	Lumier	25036637
Intra	CDC37	Q16543	AMHR2	Homo sapiens	Q16671	Lumier	25036637
Intra	CDC37	Q16543	PSKH2	Homo sapiens	Q96QS6	Lumier	25036637
Intra	CDC37	Q16543	ZNF843	Homo sapiens	Q8N446	Lumier	22939624
Intra	CDC37	Q16543	ZNF843	Homo sapiens	Q8N446	Lumier	25036637
Intra	CDC37	Q16543	HSF2BP	Homo sapiens	O75031	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	HSF2BP	Homo sapiens	O75031	Y2H Array	32296183
Intra	CDC37	Q16543	PAICS	Homo sapiens	P22234	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PAICS	Homo sapiens	P22234	Y2H Array	32296183
Intra	CDC37	Q16543	STX1A	Homo sapiens	Q16623	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	STX1A	Homo sapiens	Q16623	Validated Y2H	32296183
Intra	CDC37	Q16543	STX1A	Homo sapiens	Q16623	Y2H Array	32296183
Intra	CDC37	Q16543	CUTC	Homo sapiens	Q9NTM9	Y2H Array	32296183
Intra	CDC37	Q16543	CUTC	Homo sapiens	Q9NTM9	Validated Y2H	32296183
Intra	CDC37	Q16543	CUTC	Homo sapiens	Q9NTM9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	KATNBL1	Homo sapiens	Q9H079	Y2H Array	32296183
Intra	CDC37	Q16543	KATNBL1	Homo sapiens	Q9H079	Validated Y2H	32296183
Intra	CDC37	Q16543	KATNBL1	Homo sapiens	Q9H079	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PPP5C	Homo sapiens	P53041	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	GRIPAP1	Homo sapiens	Q4V328	Validated Y2H	32296183
Intra	CDC37	Q16543	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183
Intra	CDC37	Q16543	CGGBP1	Homo sapiens	Q9UFW8	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CGGBP1	Homo sapiens	Q9UFW8	Validated Y2H	32296183
Intra	CDC37	Q16543	CGGBP1	Homo sapiens	Q9UFW8	Y2H Array	32296183
Intra	CDC37	Q16543	MDFI	Homo sapiens	Q99750	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MDFI	Homo sapiens	Q99750	Validated Y2H	32296183
Intra	CDC37	Q16543	MDFI	Homo sapiens	Q99750	Y2H Array	32296183
Intra	CDC37	Q16543	MRPL9	Homo sapiens	Q9BYD2	Validated Y2H	32296183
Intra	CDC37	Q16543	SEPTIN3	Homo sapiens	Q9UH03	Validated Y2H	32296183
Intra	CDC37	Q16543	SEPTIN3	Homo sapiens	Q9UH03	Y2H Array	32296183
Intra	CDC37	Q16543	SEPTIN3	Homo sapiens	Q9UH03	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CEP70	Homo sapiens	Q8NHQ1	Y2H Array	32296183
Intra	CDC37	Q16543	CEP70	Homo sapiens	Q8NHQ1	Validated Y2H	32296183
Intra	CDC37	Q16543	CEP70	Homo sapiens	Q8NHQ1	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	USHBP1	Homo sapiens	Q8N6Y0	Validated Y2H	32296183
Intra	CDC37	Q16543	USHBP1	Homo sapiens	Q8N6Y0	Y2H Array	32296183
Intra	CDC37	Q16543	USHBP1	Homo sapiens	Q8N6Y0	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZBED1	Homo sapiens	O96006	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZBED1	Homo sapiens	O96006	Y2H Array	32296183
Intra	CDC37	Q16543	THAP7	Homo sapiens	Q9BT49	Validated Y2H	32296183
Intra	CDC37	Q16543	THAP7	Homo sapiens	Q9BT49	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	THAP7	Homo sapiens	Q9BT49	Y2H Array	32296183
Intra	CDC37	Q16543	THAP1	Homo sapiens	Q9NVV9	Validated Y2H	32296183
Intra	CDC37	Q16543	THAP1	Homo sapiens	Q9NVV9	Y2H Array	32296183
Intra	CDC37	Q16543	THAP1	Homo sapiens	Q9NVV9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	MAD1L1	Homo sapiens	Q9Y6D9	Validated Y2H	32296183
Intra	CDC37	Q16543	MAD1L1	Homo sapiens	Q9Y6D9	Y2H Array	32296183
Intra	CDC37	Q16543	ZBTB8A	Homo sapiens	Q96BR9	Y2H Array	32296183
Intra	CDC37	Q16543	ZBTB8A	Homo sapiens	Q96BR9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZBTB8A	Homo sapiens	Q96BR9	Validated Y2H	32296183
Intra	CDC37	Q16543	KCTD13	Homo sapiens	Q8WZ19	Y2H Array	32296183
Intra	CDC37	Q16543	KCTD13	Homo sapiens	Q8WZ19	Validated Y2H	32296183
Intra	CDC37	Q16543	KCTD13	Homo sapiens	Q8WZ19	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	FATE1	Homo sapiens	Q969F0	Validated Y2H	32296183
Intra	CDC37	Q16543	FATE1	Homo sapiens	Q969F0	Y2H Array	32296183
Intra	CDC37	Q16543	FATE1	Homo sapiens	Q969F0	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	GFAP	Homo sapiens	P14136	Y2H Array	32296183
Intra	CDC37	Q16543	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	IFIT3	Homo sapiens	O14879	Pull Down	21163940
Intra	CDC37	Q16543	IFIT3	Homo sapiens	O14879	Y2H Array	21163940
Intra	CDC37	Q16543	IFIT3	Homo sapiens	O14879	Anti Bait CoIP	21163940
Intra	CDC37	Q16543	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	AMOTL2	Homo sapiens	Q9Y2J4	Validated Y2H	32296183
Intra	CDC37	Q16543	AMOTL2	Homo sapiens	Q9Y2J4	Y2H Array	32296183
Intra	CDC37	Q16543	KLHL2	Homo sapiens	O95198	Y2H Array	32296183
Intra	CDC37	Q16543	KLHL2	Homo sapiens	O95198	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	IKZF3	Homo sapiens	Q9UKT9	Validated Y2H	32296183
Intra	CDC37	Q16543	IKZF3	Homo sapiens	Q9UKT9	Y2H Array	32296183
Intra	CDC37	Q16543	IKZF3	Homo sapiens	Q9UKT9	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	CEP55	Homo sapiens	Q53EZ4	Validated Y2H	32296183
Intra	CDC37	Q16543	CEP55	Homo sapiens	Q53EZ4	Y2H Array	32296183
Intra	CDC37	Q16543	CEP55	Homo sapiens	Q53EZ4	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	HOMER3	Homo sapiens	Q9NSC5	Validated Y2H	32296183
Intra	CDC37	Q16543	HOMER3	Homo sapiens	Q9NSC5	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	HOMER3	Homo sapiens	Q9NSC5	Y2H Array	32296183
Intra	CDC37	Q16543	ZNF276	Homo sapiens	Q8N554	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	ZNF276	Homo sapiens	Q8N554	Validated Y2H	32296183
Intra	CDC37	Q16543	ZNF276	Homo sapiens	Q8N554	Y2H Array	32296183
Intra	CDC37	Q16543	PRPH	Homo sapiens	P41219	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	PRPH	Homo sapiens	P41219	Y2H Array	32296183
Intra	CDC37	Q16543	SYCP3	Homo sapiens	Q8IZU3	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	SYCP3	Homo sapiens	Q8IZU3	Validated Y2H	32296183
Intra	CDC37	Q16543	SYCP3	Homo sapiens	Q8IZU3	Y2H Array	32296183
Intra	CDC37	Q16543	CHUK	Homo sapiens	O15111	TAP	24189400
Intra	CDC37	Q16543	CHUK	Homo sapiens	O15111	TAP	14743216
Intra	CDC37	Q16543	CHUK	Homo sapiens	O15111	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	CHUK	Homo sapiens	O15111	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	IKBKB	Homo sapiens	O14920	TAP	14743216
Intra	CDC37	Q16543	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	26496610
Intra	CDC37	Q16543	IKBKB	Homo sapiens	O14920	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	26496610
Intra	CDC37	Q16543	IKBKG	Homo sapiens	Q9Y6K9	TAP	14743216
Intra	CDC37	Q16543	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	IKBKG	Homo sapiens	Q9Y6K9	Anti Tag CoIP	25036637
Intra	CDC37	Q16543	IKBKG	Homo sapiens	Q9Y6K9	TAP	24189400
Intra	CDC37	Q16543	TSSK6	Homo sapiens	Q9BXA6	Lumier	25036637
Intra	CDC37	Q16543	FAM118A	Homo sapiens	Q9NWS6	Y2H Prey Pooling	32296183
Intra	CDC37	Q16543	FAM118A	Homo sapiens	Q9NWS6	Validated Y2H	32296183
Intra	CDC37	Q16543	FAM118A	Homo sapiens	Q9NWS6	Y2H Array	32296183
Intra	CDC37	Q16543	FBXW2	Homo sapiens	Q9UKT8	Lumier	22939624
Intra	CDC37	Q16543	FBXW2	Homo sapiens	Q9UKT8	Lumier	25036637
Intra	CDC37	Q16543	RPS6KA1	Homo sapiens	Q15418	Anti Tag CoIP	33961781
Intra	CDC37	Q16543	RPS6KA1	Homo sapiens	Q15418	TAP	24189400
Intra	CDC37	Q16543	CDK13	Homo sapiens	Q14004	Lumier	25036637
Intra	CDC37	Q16543	STK38L	Homo sapiens	Q9Y2H1	Lumier	25036637
Cross	CDC37	Q16543	EIF2AK1	Oryctolagus cuniculus	P33279	Pull Down	11036079
Cross	CDC37	Q16543	hsp90_rabit	Oryctolagus cuniculus	P11500	Anti Tag CoIP	11036079
Cross	CDC37	Q16543	hsp90_rabit	Oryctolagus cuniculus	P11500	Pull Down	11036079

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CDC37 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75364	CDC37 Protein, Human (sf9, GST)	Q16543 (M1-V378)	≥ 90%, as determined by reducing SDS-PAGE.

CDC37 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80960	CDC37 Antibody	WB, IHC-P, IP, FC	Human, Mouse, Rat
HY-P80961	Phospho-CDC37 (Ser13) Antibody	WB, IP	Human, Mouse, Rat
HY-P80962	Phospho-CDC37 (Ser13) Antibody (YA219)	WB, IP	Human, Mouse, Rat
HY-P80962A	Phospho-CDC37 (Ser13) Antibody (YA219)(PBS only)	WB, IP	Human, Mouse, Rat
HY-P84613	CDC37 Antibody (YA4310)	WB, FC, ELISA	Human, Mouse
HY-P84613A	CDC37 Antibody (YA4310)(PBS only)	WB, FC, ELISA	Human, Mouse
HY-P86580	Phospho-CDC37(Ser13) Antibody (YA6272)	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Macular Degeneration, Age-Related, 15	Age Related Macular Degeneration 15 ARMD15 Macular Degeneration, Age-Related, 15, Susceptibility To Macular Degeneration, Age-Related, Type 15

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (14)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-139301	DDO-5936	Inhibitor	98.33%	Unkown
HY-N1986	Cucurbitacin D		99.93%	Unkown
HY-144650	Hsp90-Cdc37-IN-3		98.09%	Unkown
HY-119906	Conglobatin		95.48%	Unkown
HY-169947	DDO-6079	Inhibitor	98.92%	Unkown
HY-111414	Hsp90-Cdc37-IN-1	Inhibitor	99.66%	Unkown
HY-147125	DDO-6600		99.2%	Unkown
HY-N3417	Kongensin A		98.0%	Unkown
HY-130624	Hsp90-Cdc37-IN-2		/	Unkown
HY-174347	Hsp90-Cdc37-IN-4		/	Unkown
HY-RS02297	CDC37 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS02298	CDC37L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17502	Cdc37 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23959	Cdc37 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	CDC37	VGNC	VGNC:38994
Rattus norvegicus	CDC37	RGD	RGD:71006
Bos taurus	CDC37	VGNC	VGNC:106679
Mus musculus	CDC37	MGD	MGI:109531
Macaca mulatta	CDC37	VGNC	VGNC:108494
Others	CDC37	NCBI