COA1 - cytochrome c oxidase assembly factor 1 Gene
Also Known as C7orf44; MITRAC15
Species: Homo sapiens
About COA1
This gene has 19 transcripts (splice variants) and 150 orthologues. Ubiquitous expression in lymph node (RPKM 6.8), appendix (RPKM 4.6) and 25 other tissues.
Summary
Involved in mitochondrial cytochrome c oxidase assembly and mitochondrial respiratory chain complex I assembly. Located in cytosol and mitochondrion. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
COA1 Products (27)
| mRNA | Protein | Name |
|---|---|---|
| NM_001321197.2 | NP_001308126.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001321198.2 | NP_001308127.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001321199.2 | NP_001308128.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001321200.2 | NP_001308129.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001321201.2 | NP_001308130.1 | cytochrome c oxidase assembly factor 1 homolog isoform b |
| NM_001321202.2 | NP_001308131.1 | cytochrome c oxidase assembly factor 1 homolog isoform c |
| NM_001321203.2 | NP_001308132.1 | cytochrome c oxidase assembly factor 1 homolog isoform c |
| NM_001321204.2 | NP_001308133.1 | cytochrome c oxidase assembly factor 1 homolog isoform c |
| NM_001321205.2 | NP_001308134.1 | cytochrome c oxidase assembly factor 1 homolog isoform c |
| NM_001350924.2 | NP_001337853.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001350925.2 | NP_001337854.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001350926.2 | NP_001337855.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001350927.2 | NP_001337856.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001350928.2 | NP_001337857.1 | cytochrome c oxidase assembly factor 1 homolog isoform d |
| NM_001371307.1 | NP_001358236.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371308.1 | NP_001358237.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371309.1 | NP_001358238.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371310.1 | NP_001358239.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371311.1 | NP_001358240.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371312.1 | NP_001358241.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371313.1 | NP_001358242.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371314.1 | NP_001358243.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371315.1 | NP_001358244.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371316.1 | NP_001358245.1 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| NM_001371317.1 | NP_001358246.1 | cytochrome c oxidase assembly factor 1 homolog isoform d |
| NM_001371318.1 | NP_001358247.1 | cytochrome c oxidase assembly factor 1 homolog isoform e |
| NM_018224.4 | NP_060694.2 | cytochrome c oxidase assembly factor 1 homolog isoform a |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32320651 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| involved in mitochondrial cytochrome c oxidase assembly |
IMP
IMP: Inferred from mutant phenotype
|
23260140 | GOA |
| involved in mitochondrial respiratory chain complex I assembly |
IMP
IMP: Inferred from mutant phenotype
|
23260140 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| located in mitochondrial inner membrane |
IDA
IDA: Inferred from direct assay
|
23260140 | GOA |
COA1 Protein Structure
Coa1: Cytochrome oxidase complex assembly protein 1 (20 - 133)
- 0
- 100
- 146 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
cytochrome c oxidase assembly factor 1 homolog |
|
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Mitochondrial Complex Iv Deficiency, Nuclear Type 1 |
|
|
| Leigh Syndrome |
|
|