ZG16 - zymogen granule protein 16 Gene

Also Known as JCLN; JCLN1; ZG16A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 653808

About ZG16

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:29,778,256-29,782,973 (from NCBI)

This gene has 1 transcript (splice variant) and 128 orthologues. Biased expression in colon (RPKM 333.1), small intestine (RPKM 82.8) and 1 other tissue.

Summary

Predicted to enable carbohydrate binding activity and peptidoglycan binding activity. Predicted to be involved in protein transport. Predicted to act upstream of or within defense response to Gram-positive bacterium and suppression of symbiont entry into host. Located in Golgi lumen and collagen-containing extracellular matrix. [provided by Alliance of Genome Resources, Apr 2022]

ZG16 Products (1)

mRNA Protein Name
NM_152338.4 NP_689551.3 zymogen granule membrane protein 16 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
Cellular Component GO Annotation Evidence References Source
located in Golgi lumen IDA
IDA: Inferred from direct assay
17307141 GOA
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
17307141 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZG16 Protein Structure

Jacalin

Jacalin: Jacalin-like lectin domain (41 - 158)

  • 0
  • 100
  • 167 a.a.
Protein Preferred Names Protein Names

zymogen granule membrane protein 16

  • jacalin-like lectin domain containing

ZG16 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
ZG16 O60844 UBE2I Homo sapiens Q7KZS0
Y2H Prey Pooling
32296183
Intra
ZG16 O60844 UBE2I Homo sapiens Q7KZS0
Y2H Array
32296183
Intra
ZG16 O60844 UBE2I Homo sapiens Q7KZS0
Validated Y2H
32296183
Intra
ZG16 O60844 PUF60 Homo sapiens Q9UHX1
Y2H Prey Pooling
25416956
Intra
ZG16 O60844 PUF60 Homo sapiens Q9UHX1-2
Validated Y2H
32296183
Intra
ZG16 O60844 CTNNA3 Homo sapiens Q9UI47-2
Validated Y2H
32296183
Intra
ZG16 O60844 ASPH Homo sapiens Q12797-6
Validated Y2H
32296183
Intra
ZG16 O60844 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
ZG16 O60844 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
16713569
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
ZG16 O60844 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Intra
ZG16 O60844 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Intra
ZG16 O60844 SGTB Homo sapiens Q96EQ0
Validated Y2H
32296183
Intra
ZG16 O60844 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
ZG16 O60844 GLYCTK Homo sapiens Q8IVS8
Validated Y2H
32296183
Intra
ZG16 O60844 KCNIP3 Homo sapiens Q9Y2W7
Y2H Prey Pooling
32296183
Intra
ZG16 O60844 KCNIP3 Homo sapiens Q9Y2W7
Validated Y2H
32296183
Intra
ZG16 O60844 KCNIP3 Homo sapiens Q9Y2W7
Y2H Array
32296183
Intra
ZG16 O60844 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
ZG16 O60844 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
ZG16 O60844 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ZG16 Proteins

Cat. No. Product Name Accession Purity
HY-P71037 ZG16 Protein, Human (HEK293, His) AAH29149.1 (N17-C167) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P77285 ZG16 Protein, Human (HEK293, Fc) O60844 (N17-C167) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome 1

  • Eec Syndrome

  • Rudiger Syndrome 1

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome 1

  • EEC1

  • Eec Syndrome 1

  • Eec Syndrome-1

  • Walker-Clodius Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Palate Syndrome

  • Eec

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip-Palate Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

  • Ectrodactyly-Cleft Lip/Palate Syndrome

  • Ectrodactyly-Ectodermal Dysplasia-Cleft Lip/Cleft Palate

  • Ectrodactyly-Ectodermal Dysplasia-Clefting Syndrome

  • Ectrodactyly, Ectodermal Dysplasia, Clefting Syndrome

  • Ectrodactyly-Cleft Lip-Palate Syndrome

  • Ectrodactyly, Ectodermal Dysplasia, And Cleft Lip/Palate Syndrome
Spondylocostal Dysostosis 5

  • Spondylothoracic Dysostosis

  • SCDO5

  • Jarcho-Levin Syndrome

  • Scoliosis, Congenital, With Or Without Rib Anomalies

  • Tacs

  • Spondylocostal Dysplasia

  • Costovertebral Segmentation Anomalies

  • Spondylocostal Dysostosis 1

  • Spondylocostal Dysostosis

  • Spondylothoracic Dysplasia

  • Scdo1

  • Spondylocostal Dysostosis 1 Autosomal Recessive

  • Costovertebral Dysplasia

  • Scdo

  • Std

  • Autosomal Dominant Spondylocostal Dysostosis

  • Autosomal Dominant Spondylocostal Dysplasia

  • Doid:0112363

  • Spondylocostal Dysostosis 4, Autosomal Dominant
Colon Mucinous Adenocarcinoma

  • Colonic Mucinous Adenocarcinoma

  • Mucinous Adenocarcinoma Of The Colon
Episodic Kinesigenic Dyskinesia 1

  • Paroxysmal Kinesigenic Choreoathetosis

  • Paroxysmal Kinesigenic Dyskinesia

  • Dystonia 10

  • Familial Paroxysmal Kinesigenic Dyskinesia

  • Episodic Kinesigenic Dyskinesia

  • EKD1

  • Pkc

  • Pkd

  • Dyt10

  • Familial Pkd

  • Paroxysmal Kinesigenic Choreathetosis

  • Familial Paroxysmal Dystonia

  • Dystonia, Familial Paroxysmal

  • Dyt-Prrt2

  • Dystonia, Type 10
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS16063 ZG16 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS16064 ZG16B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20842 Zg16 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25177 Zg16b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27356 Zg16 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ZG16 VGNC VGNC:104766
Bos taurus ZG16 VGNC VGNC:37180
Canis familiaris ZG16 VGNC VGNC:48629
Rattus norvegicus ZG16 RGD RGD:620346
Mus musculus ZG16 MGD MGI:1916286
Others ZG16 NCBI