2. Apoptosis Stem Cell/Wnt
  3. Apoptosis Hedgehog Gli
  4. GLI1-IN-1

GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway.

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GLI1-IN-1

GLI1-IN-1 화학구조

CAS No. : 2923907-92-8

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제품 설명

GLI1-IN-1 (CBC-1) is a GLI-1 inhibitor with excellent water solubility and anticancer activity. GLI1-IN-1 can induce apoptosis and suppress the growth of colorectal cancer by inhibiting the Hedgehog(HH) (IC50=1.3 μM) pathway[1].

IC50 & Target

IC50: 1.3 μM (Hedgehog)[1].
In Vitro

GLI1-IN-1 (CBC-1) (5-40 μM; 24-48 h) exhibits anticancer activity by inhibiting cell proliferation through suppressing the mRNA and protein expression of the HH pathway in HT-29, SW-480, and HCT-116 cells, with IC50 values of 7.13, 15.31, and 3.33 μM, respectively. GLI1-IN-1 (5-40 μM; 24 h) can also induce apoptosis in HT-29 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GLI1-IN-1 Related Antibodies

Apoptosis Analysis[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h
Result: Increased the number of apoptotic cells in a concentration-dependent manner.

RT-PCR[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h, 48 h
Result: Decreased the mRNA expression of SHH, SMO, GLI1, and PTCH in a concentration- and time-dependent manner.
Significantly reduced the mRNA expression levels of the apoptosis-related factor BCL-2 and increased the levels of the apoptosis-promoting factor BAX in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HT-29
Concentration: 5, 10, 20, 40 µM;
Incubation Time: 24 h
Result: Decreased the protein expression of SHH, SMO and GLI1 in a concentration-dependent manner.
In Vivo

CBC-1 (50 mg/kg; i.p.; once daily for 16 days) can effectively inhibit tumor growth in xenograft models, with a remarkable tumor inhibition rate of 68% in BALB/c/nu/nu nude mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Tumour xenograft BALB/c/nu/nu nude mice model[1].
Dosage: 50 mg/kg
Administration: Intraperitoneal injection (i.p.); Once daily for 16 days
Result: Significantly reduced the size and weight of HT29 tumor xenografts.
Decreased the protein expression of GLI -1.
분자량

736.93

화학식

C42H60N2O9
CAS No.
SMILES

CN1CCN(CC(O[C@@H]2CC3=CC[C@]([C@](CC[C@@]4(O)[C@@H](OC([C@@H](C)CC)=O)C)(O)[C@]4(C)[C@H](OC(/C=C/C5=CC=CC=C5)=O)C6)(O)C6[C@@]3(C)CC2)=O)CC1
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
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Keywords:

GLI1-IN-12923907-92-8ApoptosisHedgehogGliColorectal cancer (CRC)HT-29SW-480HCT-116apoptosisInhibitorinhibitorinhibit

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