Glufosinate 

Glufosinate, a phosphinic acid analogue of glutamic acid, is a herbicide which is converted by plant cells into PT (L-phosphinothricin). Glufosinate exerts neurotoxic activity^[1][2].

Glufosinate (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs)^[2].
Glufosinate (1-100 μM; 12DIV) significantly decreases Celsr2 gene expression at 100 μM^[2].
Glufosinate impairs ependymal cell capability to synthetize cilia^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glufosinate (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) indicates maternal toxicity in the groups given 50 or 250 mg/kg in Wistar rats^[3].
The Elimination of Glufosinate (oral intubation) in the blood takes place with a half-life of less than 4 hours in male and female rats^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

181.13

C₅H₁₂NO₄P

51276-47-2

Solid

Light brown to brown

CP(O)(CCC(N)C(O)=O)=O

Room temperature in continental US; may vary elsewhere.

• [1]. Áy Z, et al. The effect of high concentrations of glufosinate ammonium on the yield components of transgenic spring wheat (Triticum aestivum L.) constitutively expressing the bar gene. ScientificWorldJournal. 2012;2012:657945.  [Content Brief]

  [2]. Feat-Vetel J, et al. Multiple effects of the herbicide glufosinate-ammonium and its main metabolite on neural stem cells from the subventricular zone of newborn mice. Neurotoxicology. 2018 Dec;69:152-163.  [Content Brief]

  [3]. Ebert E, et al. Summary of safety evaluation toxicity studies of glufosinate ammonium. Food Chem Toxicol. 1990 May;28(5):339-49.  [Content Brief]