2. Apoptosis
  3. RIP kinase
  4. GSK2983559

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples.

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GSK2983559

GSK2983559 Chemische Struktur

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Based on 2 publication(s) in Google Scholar

Other Forms of GSK2983559:

GSK2983559 Related Antibodies

Top Publications Citing Use of Products

2 Publications Citing Use of MCE GSK2983559

Alle RIP kinase Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen
RIPK1 RIPK2 RIPK3

  • Biologische Aktivität

  • Reinheit & Dokumentation

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Beschreibung

GSK2983559 is an orally active and potent receptor interacting protein 2 (RIP2) kinase inhibitor. GSK2983559 blocks many proinflammatory cytokine responses in vivo and in human inflammatory bowel disease explant samples[1].

IC50 & Target[1]

RIPK2

 

In Vitro

GSK2983559 (1-1024 nM; 2 h) blocks MDP-induced IL-8 in THP-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GSK2983559 Related Antibodies

Cell Viability Assay[2]

Cell Line: THP-1 cells
Concentration: 1-1024 nM
Incubation Time: 2 hours
Result: Inhibited IL-8 production with an IC50 of 1.34 nM.
In Vivo

GSK2983559 (oral gavage; 3 and 10 mg/kg; once) inhibits effectively MDP-induced IL-6 in mouse[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mice (female) injected with MDP (100 μg)[2]
Dosage: 3 and 10 mg/kg
Administration: Oral gavage; 3 and 10 mg/kg; once
Result: Suppressed serum IL-6 levels in a dose-dependent manner.
Molekulargewicht

612.63

Formel

C21H23N4O7PS2.1/2Ca.3H2O
Appearance

Solid

Color

Yellow to brown

SMILES

CC(C)(C)S(C(C(OCCOP(O)([O-])=O)=CC1=NC=N2)=CC1=C2NC3=CC(N=CS4)=C4C=C3)(=O)=O.[H]O[H].[H]O[H].[H]O[H].[Ca+2]
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : < 1 mg/mL (insoluble or slightly soluble)

DMF : < 1 mg/mL (insoluble)

Ethanol : < 1 mg/mL (insoluble)

*GSK2983559 is usually formulated as a suspension.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise
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GSK2983559 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GSK2983559GSK 2983559GSK-2983559RIP kinaseReceptor-interacting protein kinasesRIPKTHP-1 cellInhibitorinhibitorinhibit

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