Hydrotecan-NH-L-Ala-L-Val-L-Gln(CO-C5-succinimide)-D-glucitol

Art. -Nr.: HY-178275 Reinheit: 98.26%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Hydrotecan-NH-L-Ala-L-Val-L-Gln(CO-C5-succinimide)-D-glucitol (Example 9) is a conjugate of the ADC toxic molecule and the linker, where the toxic molecule part is Hydrotecan (HY-164378), and the linker part is Mc-Glu(D-Glucamine)-val-ala (HY-178309) .

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Hydrotecan-NH-L-Ala-L-Val-L-Gln(CO-C5-succinimide)-D-glucitol Chemische Struktur

CAS. Nr. : 2694026-77-0

Größe	Verfügbarkeit	Menge
1 mg	Auf Lager	Estimated Time of Arrival: December 31
5 mg	Auf Lager	Estimated Time of Arrival: December 31
10 mg	Angebot einholen
50 mg	Angebot einholen

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Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Drug-Linker Conjugates for ADC Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Auristatin Camptothecins Daunorubicins/Doxorubicins Duocarmycins Maytansinoids Pyrrolobenzodiazepines Traditional Cytotoxic Agents Dual payloads

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

Molekulargewicht

1137.21

Formel

C₅₅H₇₃FN₈O₁₇

CAS. Nr.

2694026-77-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C1N2C(C(C(C2)=CC3=C4CCCCOCNC([C@H](C)NC([C@H](C(C)C)NC([C@@H](NC(CCCCCN5C(C=CC5=O)=O)=O)CCC(NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)=O)=O)=O)=O)=NC3=CC(F)=C4C)=CC6=C1COC([C@]6(O)CC)=O

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : ≥ 100 mg/mL (87.93 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.8793 mL	4.3967 mL	8.7935 mL
5 mM	0.1759 mL	0.8793 mL	1.7587 mL
10 mM	0.0879 mL	0.4397 mL	0.8793 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

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Working solution concentration: mg/mL

Reinheit & Dokumentation

Purity: 98.26%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (252 KB) HNMR (307 KB) RP-HPLC (226 KB) LCMS (96 KB)

Handling Instructions (2659 KB)

Verweise

[1]. Wei Li, et al. Auristatin derivatives and conjugates thereof. WO2024023735A1.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	0.8793 mL	4.3967 mL	8.7935 mL	21.9836 mL
	5 mM	0.1759 mL	0.8793 mL	1.7587 mL	4.3967 mL
	10 mM	0.0879 mL	0.4397 mL	0.8793 mL	2.1984 mL
	15 mM	0.0586 mL	0.2931 mL	0.5862 mL	1.4656 mL
	20 mM	0.0440 mL	0.2198 mL	0.4397 mL	1.0992 mL
	25 mM	0.0352 mL	0.1759 mL	0.3517 mL	0.8793 mL
	30 mM	0.0293 mL	0.1466 mL	0.2931 mL	0.7328 mL
	40 mM	0.0220 mL	0.1099 mL	0.2198 mL	0.5496 mL
	50 mM	0.0176 mL	0.0879 mL	0.1759 mL	0.4397 mL
	60 mM	0.0147 mL	0.0733 mL	0.1466 mL	0.3664 mL
	80 mM	0.0110 mL	0.0550 mL	0.1099 mL	0.2748 mL