2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. Infigratinib-d3

Infigratinib-d3  (Synonyms: BGJ-398-d3; NVP-BGJ398-d3)

Art. -Nr.: HY-13311S Reinheit: 98.90%
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Handling Instructions Technical Support

Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively.

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Infigratinib-d<sub>3</sub>

Infigratinib-d3 Chemische Struktur

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Other Forms of Infigratinib-d3:

Infigratinib-d3 Related Antibodies

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Beschreibung

Infigratinib-d3 is a deuterated analog of infigratinib. Infigratinib is an effective inhibitor of the FGFR family, with IC50 values of 0.9 nM, 1.4 nM, 1 nM, and 60 nM for FGFR1, FGFR2, FGFR3, and FGFR4, respectively[1].

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Molekulargewicht

563.49

Formel

C26H28D3Cl2N7O3
Unlabeled CAS
Appearance

Solid

Color

Yellow to brown

SMILES

CCN1CCN(C2=CC=C(NC3=NC=NC(N(C([2H])([2H])[2H])C(NC4=C(Cl)C(OC)=CC(OC)=C4Cl)=O)=C3)C=C2)CC1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Lösungsmittel & Löslichkeit
In Vitro: 

DMSO : 12 mg/mL (21.30 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7747 mL 8.8733 mL 17.7465 mL
5 mM 0.3549 mL 1.7747 mL 3.5493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molaritätsrechner

  • Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Reinheit & Dokumentation
Verweise

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7747 mL 8.8733 mL 17.7465 mL 44.3664 mL
5 mM 0.3549 mL 1.7747 mL 3.5493 mL 8.8733 mL
10 mM 0.1775 mL 0.8873 mL 1.7747 mL 4.4366 mL
15 mM 0.1183 mL 0.5916 mL 1.1831 mL 2.9578 mL
20 mM 0.0887 mL 0.4437 mL 0.8873 mL 2.2183 mL
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Infigratinib-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Infigratinib-d3BGJ-398-d3 NVP-BGJ398-d3FGFRFibroblast growth factor receptordeuterated analogcancerInhibitorinhibitorinhibit

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