2. Natural Products
  3. Plants Alkaloids Phenols
  4. Lauraceae Piperidine Alkaloids Polyphenols
  5. Lindera aggregata (Sims) Kosterm.
  6. Isoboldine

Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice.

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Isoboldine

Isoboldine 화학구조

CAS No. : 3019-51-0

사이즈 가격 재고 수량
1 mg 해외재고보유
5 mg 견적 받기
10 mg   견적 받기  
50 mg   견적 받기  

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Isoboldine Related Antibodies

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제품 설명

Isoboldine is a pyridine alkaloid. Isoboldine effectively alleviates inflammation and joint destruction in collagen-induced arthritis in mice[1].

Cellular Effect
Cell Line Type Value Description References
B-cell IC50
29.6 3
Compound: 15
Inhibition of LPS-induced BALB/c mouse B cell proliferation
Inhibition of LPS-induced BALB/c mouse B cell proliferation
[PMID: 17081761]
Neutrophil IC50
5.81 3
Compound: (+)-Isoboldine
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
[PMID: 32359855]
Neutrophil IC50
5.81 3
Compound: (+)-Isoboldine
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
[PMID: 32359855]
Neutrophil IC50
5.81 3
Compound: (+)-Isoboldine
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
Antiinflammatory activity in human neutrophils assessed as inhibition of fMLF/cytochalasin B-induced superoxide anion generation preincubated for 5 mins followed by fMLF addition after priming with CB for 3 mins by spectrophotometric analysis
[PMID: 32359855]
T-cell IC50
24 3
Compound: 15
Inhibition of ConA-induced BALB/c mouse T cell proliferation
Inhibition of ConA-induced BALB/c mouse T cell proliferation
[PMID: 17081761]
분자량

327.37

화학식

C19H21NO4
CAS No.
Appearance

Solid

Color

Brown to dark brown

SMILES

OC1=C2C3=C(C=C1OC)CCN(C)[C@@]3([H])CC4=CC(O)=C(OC)C=C42
Structure Classification
Initial Source
선적

Room temperature in continental US; may vary elsewhere.
보관
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
용액&용해도
In Vitro: 

DMSO : 2.5 mg/mL (7.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0546 mL 15.2732 mL 30.5465 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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순도&문서
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0546 mL 15.2732 mL 30.5465 mL 76.3662 mL
5 mM 0.6109 mL 3.0546 mL 6.1093 mL 15.2732 mL
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Isoboldine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Isoboldine3019-51-0OthersalkaloidinflammationInhibitorinhibitorinhibit

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상품명:
Isoboldine
Cat. No.:
HY-N9794
수량:
MCE Japan Authorized Agent:

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