KIKIKPWWWPKIKIK-NH2
KIKIKPWWWPKIKIK-NH2 is a β-turn antimicrobial peptide. KIKIKPWWWPKIKIK-NH2 can inhibit bacterial biofilm formation and bind to lipopolysaccharid. KIKIKPWWWPKIKIK-NH2 shows wound-healing ability in mice bacteria-infected full-thickness wound models. KIKIKPWWWPKIKIK-NH2 can be used for the research of bacterial infection.
For research use only. We do not sell to patients.
- Formula: C103H163N25O15
- Molecular Weight:1991.55
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
KIKIKPWWWPKIKIK-NH2 (Compound P-07) (18 h) displays broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacterial strains (including multidrug-resistant strains) with a geometric mean MIC of 5.00 μM[1].
KIKIKPWWWPKIKIK-NH2 (1 h) has low hemolytic activity against human red blood cells, with an HC10 greater than 256 μM[1].
KIKIKPWWWPKIKIK-NH2 (2-256 μM; 24 h) shows low cytotoxicity against BEAS-2B, HEK-293T, and LO2 human cell lines[1].
KIKIKPWWWPKIKIK-NH2 (8-16 μM; 6 h) exhibits rapid time-dependent bactericidal activity against S. aureus (MDR) and E. coli (MDR)[1].
KIKIKPWWWPKIKIK-NH2 (2-32 μM; 24 h) inhibits biofilm formation by S. aureus (MDR) and E. coli (MDR) in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Human bronchial epithelioid (BEAS-2B), human embryonic kidney (HEK-293T), human hepatic (LO2) cell lines
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Concentration:2, 4, 8, 16, 32, 64, 128, 256 μM
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Incubation Time:24 h
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Result:Exhibited low cytotoxicity against BEAS-2B, HEK-293T, and LO2 cells relative to controls.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:KM (Male, 6 weeks old, ~20 g, full-thickness wound infected with E. coli ATCC 25922 and MDR E. coli)[1]
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Dosage:100 μM
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Administration:Topical; daily; 11 days
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Result:Significantly reduced bacterial loads of E. coli ATCC 25922 and E. coli (MDR) on wound surfaces compared to controls.
Promoted wound healing, with wounds showing smaller sizes over time and almost complete healing by day 11.
Reduced inflammatory cell infiltration, vascular congestion, and IL-6 expression in treated wounds.
Chemical Information
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Molecular Weight 1991.55
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Formula C103H163N25O15
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Sequence
Lys-Ile-Lys-Ile-Lys-Pro-Trp-Trp-Trp-Pro-Lys-Ile-Lys-Ile-Lys-NH2
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Sequence Shortening
KIKIKPWWWPKIKIK-NH2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KIKIKPWWWPKIKIK-NH2 Related Classifications
HY-P11592 Related Classifications
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