2. Anti-infection
  3. Bacterial
  4. KIKIKPWWWPKIKIK-NH2

KIKIKPWWWPKIKIK-NH2 is a β-turn antimicrobial peptide. KIKIKPWWWPKIKIK-NH2 can inhibit bacterial biofilm formation and bind to lipopolysaccharid. KIKIKPWWWPKIKIK-NH2 shows wound-healing ability in mice bacteria-infected full-thickness wound models. KIKIKPWWWPKIKIK-NH2 can be used for the research of bacterial infection.

For research use only. We do not sell to patients.

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KIKIKPWWWPKIKIK-NH2

KIKIKPWWWPKIKIK-NH2 Chemical Structure

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KIKIKPWWWPKIKIK-NH2 Related Antibodies

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Description

KIKIKPWWWPKIKIK-NH2 is a β-turn antimicrobial peptide. KIKIKPWWWPKIKIK-NH2 can inhibit bacterial biofilm formation and bind to lipopolysaccharid. KIKIKPWWWPKIKIK-NH2 shows wound-healing ability in mice bacteria-infected full-thickness wound models. KIKIKPWWWPKIKIK-NH2 can be used for the research of bacterial infection[1].

In Vitro

KIKIKPWWWPKIKIK-NH2 (Compound P-07) (18 h) displays broad-spectrum antimicrobial activity against Gram-positive and Gram-negative bacterial strains (including multidrug-resistant strains) with a geometric mean MIC of 5.00 μM[1].
KIKIKPWWWPKIKIK-NH2 (1 h) has low hemolytic activity against human red blood cells, with an HC10 greater than 256 μM[1].
KIKIKPWWWPKIKIK-NH2 (2-256 μM; 24 h) shows low cytotoxicity against BEAS-2B, HEK-293T, and LO2 human cell lines[1].
KIKIKPWWWPKIKIK-NH2 (8-16 μM; 6 h) exhibits rapid time-dependent bactericidal activity against S. aureus (MDR) and E. coli (MDR)[1].
KIKIKPWWWPKIKIK-NH2 (2-32 μM; 24 h) inhibits biofilm formation by S. aureus (MDR) and E. coli (MDR) in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

KIKIKPWWWPKIKIK-NH2 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: Human bronchial epithelioid (BEAS-2B), human embryonic kidney (HEK-293T), human hepatic (LO2) cell lines
Concentration: 2, 4, 8, 16, 32, 64, 128, 256 μM
Incubation Time: 24 h
Result: Exhibited low cytotoxicity against BEAS-2B, HEK-293T, and LO2 cells relative to controls.
In Vivo

KIKIKPWWWPKIKIK-NH2 (Compound P-07) (100 μM; topical; daily; 11 days) reduces bacterial loads and inflammatory responses, promoting healing in E. coli-infected wound models in mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: KM (Male, 6 weeks old, ~20 g, full-thickness wound infected with E. coli ATCC 25922 and MDR E. coli)[1]
Dosage: 100 μM
Administration: Topical; daily; 11 days
Result: Significantly reduced bacterial loads of E. coli ATCC 25922 and E. coli (MDR) on wound surfaces compared to controls.
Promoted wound healing, with wounds showing smaller sizes over time and almost complete healing by day 11.
Reduced inflammatory cell infiltration, vascular congestion, and IL-6 expression in treated wounds.
Molecular Weight

1991.55

Formula

C103H163N25O15
Sequence

Lys-Ile-Lys-Ile-Lys-Pro-Trp-Trp-Trp-Pro-Lys-Ile-Lys-Ile-Lys-NH2
Sequence Shortening

KIKIKPWWWPKIKIK-NH2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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KIKIKPWWWPKIKIK-NH2 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

KIKIKPWWWPKIKIK-NH2BacterialLO2E. coliGram-positive bacterial strainsmultidrug-resistant bacteriaBEAS-2BGram-negative bacterial strainsHEK-293TInhibitorinhibitorinhibit

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