L-Azidohomoalanine hydrochloride

Name: L-Azidohomoalanine hydrochloride
Brand: MedChemExpress
SKU: HY-140346A
Rating: 5.0 (6 reviews)

Art. -Nr.: HY-140346A Reinheit: 98.85%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

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L-Azidohomoalanine hydrochloride Chemische Struktur

CAS. Nr. : 942518-29-8

Größe	Verfügbarkeit	Menge
50 mg	Auf Lager	Estimated Time of Arrival: December 31
100 mg	Auf Lager	Estimated Time of Arrival: December 31
250 mg	Auf Lager	Estimated Time of Arrival: December 31
1 g	Auf Lager	Estimated Time of Arrival: December 31
5 g	Auf Lager	Estimated Time of Arrival: December 31
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Based on 6 publication(s) in Google Scholar

Other Forms of L-Azidohomoalanine hydrochloride:

L-Azidohomoalanine-1,2,3,4-¹³C₄ hydrochloride Angebot einholen
L-Azidohomoalanine Angebot einholen

6 Publications Citing Use of MCE L-Azidohomoalanine hydrochloride

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle PROTAC Linkers Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

PEG Linkers Alkyl-Chain Linkers Alkyl/ether Linkers

Biologische Aktivität
Reinheit & Dokumentation
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Beschreibung

L-Azidohomoalanine hydrochloride is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs^[1]. L-Azidohomoalanine (hydrochloride) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

IC₅₀ & Target

Alkyl-Chain

In Vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

180.59

Formel

C₄H₉ClN₄O₂

CAS. Nr.

942518-29-8

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)[C@@H](N)CCN=[N+]=[N-].[H]Cl

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 100 mg/mL (553.74 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.5374 mL	27.6870 mL	55.3741 mL
5 mM	1.1075 mL	5.5374 mL	11.0748 mL
10 mM	0.5537 mL	2.7687 mL	5.5374 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner
Verdünnungsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS
Solubility: 100 mg/mL (553.74 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Reinheit & Dokumentation

Purity: 98.85%

Select Batch:

Data Sheet (271 KB) SDS (466 KB)

COA (306 KB) HNMR (243 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

Verweise

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	5.5374 mL	27.6870 mL	55.3741 mL	138.4351 mL
	5 mM	1.1075 mL	5.5374 mL	11.0748 mL	27.6870 mL
	10 mM	0.5537 mL	2.7687 mL	5.5374 mL	13.8435 mL
	15 mM	0.3692 mL	1.8458 mL	3.6916 mL	9.2290 mL
	20 mM	0.2769 mL	1.3844 mL	2.7687 mL	6.9218 mL
	25 mM	0.2215 mL	1.1075 mL	2.2150 mL	5.5374 mL
	30 mM	0.1846 mL	0.9229 mL	1.8458 mL	4.6145 mL
	40 mM	0.1384 mL	0.6922 mL	1.3844 mL	3.4609 mL
	50 mM	0.1107 mL	0.5537 mL	1.1075 mL	2.7687 mL
	60 mM	0.0923 mL	0.4615 mL	0.9229 mL	2.3073 mL
	80 mM	0.0692 mL	0.3461 mL	0.6922 mL	1.7304 mL
	100 mM	0.0554 mL	0.2769 mL	0.5537 mL	1.3844 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.