2. Vitamin D Related/Nuclear Receptor
  3. Progesterone Receptor
  4. Lonaprisan

Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect.

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Lonaprisan

Lonaprisan Estructura química

No. CAS : 211254-73-8

Tamaño Precio Stock Cantidad
5 mg Obtener un presupuesto 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 7 - 9 weeks
10 mg Obtener un presupuesto 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 7 - 9 weeks
25 mg Obtener un presupuesto 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 7 - 9 weeks
50 mg Obtener un presupuesto 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 7 - 9 weeks
100 mg Obtener un presupuesto 7 - 9 weeks 6 - 8 weeks 8 - 10 weeks 7 - 9 weeks
200 mg   Obtener un presupuesto  
500 mg   Obtener un presupuesto  
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Lonaprisan Related Antibodies

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Descripciòn

Lonaprisan (ZK 230211; BAY86 5044) is an antagonist for progesterone receptor, with IC50 of 3.6 pM and 2.5 pM for PR-A and PR-B, respectively. Lonaprisan exhibits antiprogestagenic activity in rabbits, interrupts early pregnancy in rats, and exhibits antitumor efficacy against DMBA (HY-W011845)-induced mammary tumor. Lonaprisan reveals antiglucocorticoid and antiandrogenic effect[1].

IC50 & Target

IC50: 3.6 pM (progesterone receptor A), 2.5 pM (progesterone receptor B)
Cellular Effect
Cell Line Type Value Description References
CV-1 IC50
54 nM
Compound: ZK-230211
In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor
In vitro antagonist potency in transactivation assay in CV-1 cells expressing androgen receptor
[PMID: 11150172]
NIH3T3 IC50
16 nM
Compound: ZK-230211
In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
In vitro antagonist potency in transactivation assay in NIH3T3 cells expressing glucocorticoid receptor
[PMID: 11150172]
Ensayo clínico
Peso molecular

508.52

Fòrmula

C28H29F5O3
No. CAS
SMILES

O=C1CCC2=C3[C@@H](C4=CC=C(C(C)=O)C=C4)C[C@@]5(C)[C@](CC[C@@]5(O)C(F)(C(F)(F)F)F)([H])[C@]3([H])CCC2=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
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Lonaprisan Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lonaprisan211254-73-8ZK 230211 BAY86 5044ZK230211ZK-230211Progesterone ReceptorNR3C3Juvenile rabbitWistar ratendometriosisleiomyomasbreast cancer,RU 486Inhibitorinhibitorinhibit

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Nombre del producto:
Lonaprisan
Cat. No.:
HY-16290
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