1. Apoptosis
  2. Apoptosis
  3. Lupiwighteone

Lupiwighteone 

Cat. No.: HY-N3354
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Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway.

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Lupiwighteone Chemical Structure

Lupiwighteone Chemical Structure

CAS No. : 104691-86-3

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Description

Lupiwighteone is an isoflavone present widely in wild-growing plants, with antioxidant, antimicrobial and anticancer effects. Lupiwighteone induces caspase-dependent and -independent apoptosis on human breast cancer cells via inhibiting PI3K/Akt/mTOR pathway[1][2].

IC50 & Target

apoptosis[2]

In Vitro

Lupiwighteone (2-100 μM; 72 hours) shows cytotoxicity towards various cell lines, especially on DU-145 cells and SGC-7901 cells with IC50s of 23.7 μM and 21 μM, respectively[2].
Lupiwighteone (20-60 μM; 48 hours) induces (cell cycle arrest in DU-145 cells[2].
Lupiwighteone (20-60 μM; 48 hours) induces cells apoptosis[2].
Lupiwighteone (20-60 μM; 48 hours) decreases the cell cycle-related protein expressions in a dose-dependent manner in DU-145 cells[2].
Lupiwighteone (20-60 μM; 48 hours) induces a dose-dependent increase in ROS production[2].
Lupiwighteone up-regulates of cytochrome c and caspase-3, and subsequent cleavage of PARP-1 and down-regulates of the p-Akt/Akt ratio and VEGF expression, suggests the activation of mitochondria-based intrinsic apoptosis in DU-145 cells[2].

Cell Viability Assay[2]

Cell Line: DU-145 cells, C4-2 cells, SGC-7901 cells, Hela cells, HUVEC, MCF-7 cells, CNE cells, Vero
Concentration: 2 μM, 5 μM, 25 μM, 50 μM, 100 μM
Incubation Time: 72 hours
Result: Had inhibition on the survival of many cancer cell lines and HUVEC.

Cell Cycle Analysis[2]

Cell Line: DU-145 cells
Concentration: 20 μM, 40 μM, 60 μM
Incubation Time: 48 hours
Result: Induced cell cycle arrest.

Apoptosis Analysis[2]

Cell Line: DU-145 cells
Concentration: 20 μM, 40 μM, 60 μM
Incubation Time: 48 hours
Result: Induced apoptosis.

Western Blot Analysis[2]

Cell Line: DU-145 cells
Concentration: 20 μM, 40 μM, 60 μM
Incubation Time: 48 hours
Result: Decreased CDK1, 2, 4, 6, cyclinD1, and cyclinB1 protein expression in a dose-dependent manner.
Molecular Weight

338.35

Formula

C₂₀H₁₈O₅

CAS No.

104691-86-3

SMILES

O=C1C2=C(O)C=C(O)C(C/C=C(C)\C)=C2OC=C1C3=CC=C(O)C=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

LupiwighteoneApoptosisisoflavoneantioxidantantimicrobialapoptosisPI3KAktmTORInhibitorinhibitorinhibit

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