Lusutrombopag-d₁₃ (Synonyms: S-888711-d₁₃)

製品番号: HY-19883S 純度: 98.64%: Data Sheet SDS COA 取扱説明書
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Lusutrombopag-d₁₃ is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

Lusutrombopag-d₁₃ 構造式

CAS 番号 : 2983162-15-6

容量	価格（税別）	在庫状況	数量
1 mg	$750	在庫あり	Estimated Time of Arrival: December 31
5 mg		お問い合わせ
10 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

Other Forms of Lusutrombopag-d₁₃:

Lusutrombopag 在庫あり

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純度とドキュメンテーション
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製品説明

Lusutrombopag-d₁₃ is deuterium labeled Lusutrombopag. Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

Application

1. This compound can be used as a tracer.
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

体外実験

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

604.63

分子式

C₂₉H₁₉D₁₃Cl₂N₂O₅S

CAS 番号

2983162-15-6

Unlabeled CAS

1110766-97-6

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C(C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OC([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])[2H])C)=C3OC)=CS2)=O)C=C1Cl

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 50 mg/mL (82.70 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.6539 mL	8.2695 mL	16.5390 mL
5 mM	0.3308 mL	1.6539 mL	3.3078 mL
10 mM	0.1654 mL	0.8270 mL	1.6539 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

純度とドキュメンテーション

純度: 98.64%

Select Batch:

データシート (271 KB) SDS (251 KB)

COA (247 KB) HNMR (1776 KB) RP-HPLC (2531 KB) MS (1445 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Kim ES, et al. Lusutrombopag: First Global Approval. Drugs. 2016 Jan;76(1):155-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.6539 mL	8.2695 mL	16.5390 mL	41.3476 mL
	5 mM	0.3308 mL	1.6539 mL	3.3078 mL	8.2695 mL
	10 mM	0.1654 mL	0.8270 mL	1.6539 mL	4.1348 mL
	15 mM	0.1103 mL	0.5513 mL	1.1026 mL	2.7565 mL
	20 mM	0.0827 mL	0.4135 mL	0.8270 mL	2.0674 mL
	25 mM	0.0662 mL	0.3308 mL	0.6616 mL	1.6539 mL
	30 mM	0.0551 mL	0.2757 mL	0.5513 mL	1.3783 mL
	40 mM	0.0413 mL	0.2067 mL	0.4135 mL	1.0337 mL
	50 mM	0.0331 mL	0.1654 mL	0.3308 mL	0.8270 mL
	60 mM	0.0276 mL	0.1378 mL	0.2757 mL	0.6891 mL
	80 mM	0.0207 mL	0.1034 mL	0.2067 mL	0.5168 mL

Lusutrombopag-d₁₃ Related Classifications

Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lusutrombopag-d₁₃2983162-15-6S-888711-d₁₃Isotope-Labeled CompoundsThrombopoietin ReceptorInhibitorinhibitorinhibit

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Lusutrombopag-d13 (Synonyms: S-888711-d13)

Other Forms of Lusutrombopag-d13:

Lusutrombopag-d13 関連抗体