1. Immunology/Inflammation
  2. Thrombopoietin Receptor
  3. Lusutrombopag

Lusutrombopag (Synonyms: S-888711)

Cat. No.: HY-19883 Purity: 99.09%
Handling Instructions

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

For research use only. We do not sell to patients.

Lusutrombopag Chemical Structure

Lusutrombopag Chemical Structure

CAS No. : 1110766-97-6

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 328 In-stock
Estimated Time of Arrival: December 31
2 mg USD 144 In-stock
Estimated Time of Arrival: December 31
5 mg USD 252 In-stock
Estimated Time of Arrival: December 31
10 mg USD 420 In-stock
Estimated Time of Arrival: December 31
25 mg USD 900 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1320 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1860 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

In Vitro

Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels[1].

Clinical Trial
Molecular Weight

591.55

Formula

C₂₉H₃₂Cl₂N₂O₅S

CAS No.

1110766-97-6

SMILES

O=C(O)/C(C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([[email protected]@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (55.79 mM)

H2O : < 0.1 mg/mL (insoluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6905 mL 8.4524 mL 16.9047 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL
10 mM 0.1690 mL 0.8452 mL 1.6905 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.5 mg/mL (4.23 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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  • Molarity Calculator

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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Keywords:

LusutrombopagS-888711S888711S 888711Thrombopoietin ReceptorInhibitorinhibitorinhibit

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Lusutrombopag
Cat. No.:
HY-19883
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