2. Immunology/Inflammation
  3. Thrombopoietin Receptor
  4. Lusutrombopag

Lusutrombopag  (Synonyms: S-888711)

Cat. No.: HY-19883 Purity: 98.32%
COA Handling Instructions

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

For research use only. We do not sell to patients.

Lusutrombopag Chemical Structure

Lusutrombopag Chemical Structure

CAS No. : 1110766-97-6

Size Price Stock Quantity
Solid + Solvent
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 267 In-stock
Solution
10 mM * 1 mL in DMSO USD 267 In-stock
Solid
2 mg USD 130 In-stock
5 mg USD 205 In-stock
10 mg USD 325 In-stock
25 mg USD 625 In-stock
50 mg USD 1000 In-stock
100 mg USD 1600 In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lusutrombopag:

Lusutrombopag Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Lusutrombopag

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Lusutrombopag is an orally bioavailable thrombopoietin (TPO) receptor agonist, used for treatment of chronic liver disease.

In Vitro

Lusutrombopag acts selectively on the human TPO receptor and activates signal transduction pathways that promote the proliferation and differentiation of bone marrow cells into megakaryocytes, thereby increasing platelet levels[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Lusutrombopag Related Antibodies
Clinical Trial
Molecular Weight

591.55

Appearance

Solid

Formula

C29H32Cl2N2O5S
CAS No.
SMILES

O=C(O)/C(C)=C/C1=C(Cl)C=C(C(NC2=NC(C3=CC=CC([C@@H](OCCCCCC)C)=C3OC)=CS2)=O)C=C1Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : ≥ 33 mg/mL (55.79 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.6905 mL 8.4524 mL 16.9047 mL
5 mM 0.3381 mL 1.6905 mL 3.3809 mL
10 mM 0.1690 mL 0.8452 mL 1.6905 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: 2.5 mg/mL (4.23 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (4.23 mM); Clear solution

*All of the co-solvents are available by MedChemExpress (MCE).
Purity & Documentation
References
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Lusutrombopag Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Lusutrombopag1110766-97-6S-888711S888711S 888711Thrombopoietin ReceptorInhibitorinhibitorinhibit

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