2. Academic Validation
  3. The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups

The discovery of anthranilic acid-based MMP inhibitors. Part 2: SAR of the 5-position and P1(1) groups

  • Bioorg Med Chem Lett. 2001 Aug 20;11(16):2189-92. doi: 10.1016/s0960-894x(01)00419-x.
J I Levin 1,  J Chen,  M Du,  M Hogan,  S Kincaid,  F C Nelson,  A M Venkatesan,  T Wehr,  A Zask,  J DiJoseph,  L M Killar,  S Skala,  A Sung,  M Sharr,  C Roth,  G Jin,  R Cowling,  K M Mohler,  R A Black,  C J March,  J S Skotnicki
Affiliations

Affiliation

  • 1 Wyeth-Ayerst Research, 401 N. Middletown Rd., Pearl River, NY 10965, USA. [email protected]
PMID: 11514167 DOI: 10.1016/s0960-894x(01)00419-x
Abstract

A novel series of anthranilic acid-based inhibitors of MMP-1, MMP-9, MMP-13, and TACE was prepared and evaluated. Selective inhibitors of MMP-9, MMP-13, and TACE were identified, including the potent, orally active MMP-13 Inhibitor 4p.

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