2. Academic Validation
  3. Biosynthesis of hyperforin in Hypericum perforatum

Biosynthesis of hyperforin in Hypericum perforatum

  • J Med Chem. 2002 Oct 10;45(21):4786-93. doi: 10.1021/jm0209782.
Petra Adam 1,  Duilio Arigoni,  Adelbert Bacher,  Wolfgang Eisenreich
Affiliations

Affiliation

  • 1 Lehrstuhl für Organische Chemie und Biochemie, Technische Universität München, Lichtenbergstrasse 4, D-85747 Garching, Germany.
PMID: 12361406 DOI: 10.1021/jm0209782
Abstract

Cut sprouts of Hypericum perforatum were proffered solutions containing [1-(13)C]glucose or [U-(13)C(6)]glucose. Hyperforin was isolated and analyzed by quantitative NMR spectroscopy. The labeling patterns show that the biosynthesis of hyperforin involves five isoprenoid moieties, which are derived entirely or predominantly (>98%) via the deoxyxylulose phosphate pathway. The phloroglucinol moiety is generated via a polyketide type mechanism.

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