2. Academic Validation
  3. Current developments in the discovery and design of new drug candidates from plant natural product leads

Current developments in the discovery and design of new drug candidates from plant natural product leads

  • J Nat Prod. 2004 Feb;67(2):273-83. doi: 10.1021/np030373o.
Kuo-Hsiung Lee 1
Affiliations

Affiliation

  • 1 Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7360, USA. [email protected]
PMID: 14987069 DOI: 10.1021/np030373o
Abstract

This review article will emphasize recent research in the Natural Products Laboratory, School of Pharmacy, University of North Carolina at Chapel Hill, on various classes of plant-derived compounds that possess potent antitumor or anti-HIV activity. These compounds were obtained by bioactivity- and mechanism of action-directed isolation and characterization coupled with rational drug design-based modification and analogue synthesis. Structural modification, SAR, and mechanism of action studies are discussed.

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