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Cat. No.: HY-135255

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NSC 660028

NSC 660028 is a DNA topoisomerase II (DNA topoisomerase II) inhibitor with an ID₅₀ of 50 μM. NSC 660028 inhibits DNA topoisomerase II and induces protein-linked DNA breaks. NSC 660028 can be used for cancer research.

For research use only. We do not sell to patients.

CAS No.: 153230-81-0
Formula: C₂₇H₂₇NO₆
Molecular Weight:461.51

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

NSC 660028 Chemical Structure

CAS No.: 153230-81-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
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Bioz

Biological Activity

Description

All Topoisomerase Isoforms :

All DNA/RNA Synthesis Isoforms :

In Vitro

NSC 660028 (Compound 21) (20-50 μM) inhibits DNA topoisomerase II activity with an ID₅₀ of 50 μM and induces greater protein-linked DNA breakage at 20 μM than Etoposide (HY-13629) at 50 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 153230-81-0
Molecular Weight 461.51
Formula C₂₇H₂₇NO₆
SMILES

N([C@@H]1C=2C([C@H]([C@@]3([C@@]1(COC3)[H])[H])C4=CC(OC)=C(O)C(OC)=C4)=CC5=C(C2)OCO5)C6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lee KH, et al. Current developments in the discovery and design of new drug candidates from plant natural product leads. J Nat Prod. 2004;67(2):273-283. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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NSC 660028

All Topoisomerase Isoforms

All DNA/RNA Synthesis Isoforms