2. Academic Validation
  3. Bioactive alkaloids from endophytic Aspergillus fumigatus

Bioactive alkaloids from endophytic Aspergillus fumigatus

  • J Nat Prod. 2009 Apr;72(4):753-5. doi: 10.1021/np800700e.
Hui Ming Ge 1,  Zhi Guo Yu,  Jie Zhang,  Jun Hua Wu,  Ren Xiang Tan
Affiliations

Affiliation

  • 1 Institute of Functional Biomolecules, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China.
PMID: 19256529 DOI: 10.1021/np800700e
Abstract

Two new Alkaloids, named 9-deacetylfumigaclavine C (1) and 9-deacetoxyfumigaclavine C (2), along with 12 known compounds (3-14), were isolated from the culture of Aspergillus fumigatus. The structures of the new compounds were elucidated by comprehensive spectroscopic analyses. Compound 2 showed selectively potent cytotoxicity against human leukemia cells (K562) with an IC(50) value of 3.1 microM, which was comparable to that of doxorubicin hydrochloride, a presently prescribed drug for the treatment of leukemia. Furthermore, 14-norpseurotin (4) significantly induced neurite outgrowth of rat pheochromocytoma cells (PC12) at a 10.0 microM concentration.

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