2. Academic Validation
  3. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis

  • Arch Pharm Res. 2009 Oct;32(10):1409-15. doi: 10.1007/s12272-009-2010-7.
Yeun-Kyung Lee 1,  Chang-Seob Seo,  Chong-Soon Lee,  Kyong-Seon Lee,  Shin-Jung Kang,  Yurngdong Jahng,  Hyun Wook Chang,  Jong-Keun Son
Affiliations

Affiliation

  • 1 College of Pharmacy, Yeungnam University, Gyongsan, Korea.
PMID: 19898804 DOI: 10.1007/s12272-009-2010-7
Abstract

Thirteen Lignans, erythro-austrobailignan-6 (1), meso-dihydroguaiaretic acid (2), sauchinone (3), 1'-epi-sauchinone (4), saucerneol D (5), manassantin B (6), manassantin A (7), nectandrin B (8), machilin D (9), saucerneol F (10), saucerneol G (11), saucerneol H (12) and saucerneol I (13), were isolated from the ethyl acetate extract of the roots of Saururus chinensis. Among these compounds, 5 showed potent inhibitory activities against DNA Topoisomerase I and II, and 5, 6, 7 and 10 showed mild cytotoxicities against HT-29 (IC(50) values; 13, 12, 11, and 10 microM, respectively) and HepG2 cell lines (IC(50) values; 16, 11, 12, and 11 microM, respectively).

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