erythro-Austrobailignan-6
erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.
For research use only. We do not sell to patients.
- CAS No.: 114127-24-1
- Formula: C20H24O4
- Molecular Weight:328.40
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
All Topoisomerase Isoforms
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Biological Activity
erythro-Austrobailignan-6 (100 μM) inhibits DNA topoisomerase I more than 50%[1].
erythro-Austrobailignan-6 (0-30 μM, 24 or 48 h) inhibits the proliferation of 4T-1 cells and MCF-7 cells[1].
erythro-Austrobailignan-6 (2-30 μM, 24 or 48 h) induces apoptosis in 4T-1 and MCF-7 cells[1].
erythro-Austrobailignan-6 (10 μM, 30-120 min) increases phosphorylation of p38 and JNK in 4T-1 and MCF-7 cells[1].
erythro-Austrobailignan-6 (5 and 10 μM, 24 h) decreases EGFR/HER2 and topoisomerase in 4T-1 and MCF-7 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:4T-1 and MCF-7 cells
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Concentration:0-30 μM
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Incubation Time:24 or 48 h
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Result:Dose dependently inhibited cell proliferation.
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Cell Line:4T-1 and MCF-7 cells
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Concentration:100 μM
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Incubation Time:30, 60 or 120 min
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Result:Increased phosphorylation of p38 and JNK.
Activated caspase-3 and inhibited CDK-4 and cyclin D1.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:4T-1 tumor bearing mice[1]
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Dosage:20 mg/kg/day
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Administration:Food intake
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Result:Inhibited tumor growth by 40.8%;
Down-regulated CDK-4, cyclin D1, HER2 and integrin β3;
Up-regulated cleaved caspase-3 in tumor.
Chemical Information
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CAS No. 114127-24-1
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Molecular Weight 328.40
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Formula C20H24O4
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SMILES
COC(C=C1C[C@@H](C)[C@@H](C)CC2=CC=C(OCO3)C3=C2)=C(C=C1)O
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Han JH, et al. Erythro-austrobailignan-6 down-regulates HER2/EGFR/integrinβ3 expression via p38 activation in breast cancer. Phytomedicine. 2017 Jan 15;24:24-30. [Content Brief]
[2]. Lee YK, et al. Inhibition of DNA topoisomerases I and II and cytotoxicity by lignans from Saururus chinensis. Arch Pharm Res. 2009 Oct;32(10):1409-15. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
erythro-Austrobailignan-6 Related Classifications
HY-N11536 Related Classifications
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