2. Cell Cycle/DNA Damage Apoptosis
  3. Topoisomerase Apoptosis
  4. erythro-Austrobailignan-6

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK.

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erythro-Austrobailignan-6 Chemical Structure

erythro-Austrobailignan-6 Chemical Structure

CAS No. : 114127-24-1

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erythro-Austrobailignan-6 Related Antibodies

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Description

erythro-Austrobailignan-6 is an orally active anti-cancer agent. erythro-Austrobailignan-6 inhibits DNA topoisomerase I and II activity. erythro-Austrobailignan-6 induces cell apoptosis and increases phosphorylation of p38 and JNK[1][2].

In Vitro

erythro-Austrobailignan-6 (100 μM) inhibits DNA topoisomerase I more than 50%[1].
erythro-Austrobailignan-6 (0-30 μM, 24 or 48 h) inhibits the proliferation of 4T-1 cells and MCF-7 cells[1].
erythro-Austrobailignan-6 (2-30 μM, 24 or 48 h) induces apoptosis in 4T-1 and MCF-7 cells[1].
erythro-Austrobailignan-6 (10 μM, 30-120 min) increases phosphorylation of p38 and JNK in 4T-1 and MCF-7 cells[1].
erythro-Austrobailignan-6 (5 and 10 μM, 24 h) decreases EGFR/HER2 and topoisomerase in 4T-1 and MCF-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

erythro-Austrobailignan-6 Related Antibodies

Cell Viability Assay[1]

Cell Line: 4T-1 and MCF-7 cells
Concentration: 0-30 μM
Incubation Time: 24 or 48 h
Result: Dose dependently inhibited cell proliferation.

Western Blot Analysis[1]

Cell Line: 4T-1 and MCF-7 cells
Concentration: 100 μM
Incubation Time: 30, 60 or 120 min
Result: Increased phosphorylation of p38 and JNK.
Activated caspase-3 and inhibited CDK-4 and cyclin D1.
In Vivo

erythro-Austrobailignan-6 (food intake, for 20 days) inhibits tumor growth in 4T-1 tumor bearing mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 4T-1 tumor bearing mice[1]
Dosage: 20 mg/kg/day
Administration: Food intake
Result: Inhibited tumor growth by 40.8%;
Down-regulated CDK-4, cyclin D1, HER2 and integrin β3;
Up-regulated cleaved caspase-3 in tumor.
Molecular Weight

328.40

Formula

C20H24O4
CAS No.
SMILES

COC(C=C1C[C@@H](C)[C@@H](C)CC2=CC=C(OCO3)C3=C2)=C(C=C1)O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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erythro-Austrobailignan-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

erythro-Austrobailignan-6114127-24-1TopoisomeraseApoptosisCancer4T-1MCF-7p38JNKInhibitorinhibitorinhibit

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