Bioactive components from the heartwood of Pterocarpus santalinus

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5630-2. doi: 10.1016/j.bmcl.2011.06.036.

Shou-Fang Wu ¹, Tsong-Long Hwang, Shu-Li Chen, Chin-Chung Wu, Emika Ohkoshi, Kuo-Hsiung Lee, Fang-Rong Chang, Yang-Chang Wu

Affiliations

Affiliation

1 Graduate Institute of Natural Products, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan.

PMID: 21784631 DOI: 10.1016/j.bmcl.2011.06.036

Abstract

One new phenanthrenedione, pterolinus K (1), and one new chalcone, pterolinus L (2) were isolated from the heartwood extract of Pterocarpus santalinus. The structures were elucidated by spectroscopic methods. Both 1 and 2 showed inhibitory effect on Elastase release by human neutrophils in response to fMLP with an IC(50) value of 4.24 and 0.95 μM, and compound 1 also inhibited superoxide anion generation with IC(50) value of 0.99 μM. In addition, compound 1 showed selective cytotoxicity against HepG2 with IC(50) value of 10.86 μM, while compound 2 showed a moderate cytotoxicity against KB with IC(50) values of 17.18 μM.

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