2. Academic Validation
  3. Urinary 1-hydroxypyrene is associated with oxidative stress and inflammatory biomarkers in acute Myocardial Infarction

Urinary 1-hydroxypyrene is associated with oxidative stress and inflammatory biomarkers in acute Myocardial Infarction

  • Int J Environ Res Public Health. 2014 Sep 1;11(9):9024-37. doi: 10.3390/ijerph110909024.
Fernando Freitas 1,  Natália Brucker 2,  Juliano Durgante 3,  Guilherme Bubols 4,  Rachel Bulcão 5,  Angela Moro 6,  Mariele Charão 7,  Marília Baierle 8,  Sabrina Nascimento 9,  Bruna Gauer 10,  Elisa Sauer 11,  Marcelo Zimmer 12,  Flávia Thiesen 13,  Iran Castro 14,  Paulo Saldiva 15,  Solange C Garcia 16
Affiliations

Affiliations

  • 1 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 2 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 3 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 4 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 5 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 6 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 7 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 8 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 9 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 10 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 11 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
  • 12 Toxicology Institute, Pharmacy Faculty, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil. [email protected].
  • 13 Toxicology Institute, Pharmacy Faculty, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, RS 90619-900, Brazil. [email protected].
  • 14 Institute of Cardiology, University Cardiology Foundation, Porto Alegre, RS 90620-000, Brazil. [email protected].
  • 15 Department of Pathology, College of Medicine, University of São Paulo, São Paulo, SP 05508-070, Brazil. [email protected].
  • 16 Toxicology Laboratory, Department of Clinical and Toxicological Analysis, Federal University of Rio Grande do Sul, Porto Alegre, RS 90610-000, Brazil. [email protected].
PMID: 25257356 DOI: 10.3390/ijerph110909024
Abstract

Several studies have associated exposure to environmental pollutants, especially polycyclic aromatic hydrocarbons (PAHs), with the development of cardiovascular diseases. Considering that 1-hydroxypyrene (1-OHP) is the major biomarker of exposure to pyrenes, the purpose of this study was to evaluate the potential association between 1-OHP and oxidative stress/inflammatory biomarkers in patients who had suffered an acute myocardial infarction (AMI). After adopting the exclusion criteria, 58 post-infarction patients and 41 controls were sub-divided into smokers and non-smokers. Urinary 1-OHP, hematological and biochemical parameters, oxidative stress biomarkers (MDA, SOD, CAT, GPx and exogenous antioxidants) and the inflammatory biomarker (hs-CRP) were analyzed. 1-OHP levels were increased in post-infarct patients compared to controls (p < 0.05) and were correlated to MDA (r = 0.426, p < 0.01), CAT (r = 0.474, p < 0.001) and β-carotene (r = -0.309; p < 0.05) in non-smokers. Furthermore, post-infarction patients had elevated hs-CRP, MDA, CAT and GPx levels compared to controls for both smokers and non-smokers. Besides, β-carotene levels and SOD activity were decreased in post-infarction patients. In summary, our findings indicate that the exposure to pyrenes was associated to lipid damage and alterations of endogenous and exogenous antioxidants, demonstrating that PAHs contribute to oxidative stress and are associated to acute myocardial infarction.

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