2. Academic Validation
  3. A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation

A mushroom-derived amino acid, ergothioneine, is a potential inhibitor of inflammation-related DNA halogenation

  • Biosci Biotechnol Biochem. 2016;80(2):313-7. doi: 10.1080/09168451.2015.1083396.
Takashi Asahi 1 2,  Xiaohong Wu 2 3,  Hiroshi Shimoda 4,  Shinsuke Hisaka 5,  Etsuko Harada 6,  Tomomi Kanno 7,  Yoshimasa Nakamura 1,  Yoji Kato 8,  Toshihiko Osawa 2 9
Affiliations

Affiliations

  • 1 a Graduate School of Environmental and Life Science , Okayama University , Okayama , Japan.
  • 2 b Graduate School of Bioagricultural Sciences , Nagoya University , Nagoya , Japan.
  • 3 c HealthCare Systems Co., Ltd. , Tokyo , Japan.
  • 4 d Oryza Oil & Fat Chemical Co., Ltd. , Ichinomiya , Japan.
  • 5 e Faculty of Pharmacy, Department of Pharmacy , Meijo University , Nagoya , Japan.
  • 6 f Iwade Research Institute of Mycology , Tsu , Japan.
  • 7 g Hokkaido University of Education , Asahikawa , Japan.
  • 8 h School of Human Science and Environment , University of Hyogo , Himeji , Japan.
  • 9 i Faculty of Psychological and Physical Science , Aichi Gakuin University , Nissin , Japan.
PMID: 26338495 DOI: 10.1080/09168451.2015.1083396
Abstract

Myeloperoxidase (MPO)-generated halogenating molecules, such as hypochlorous acid and hypobromous acid (HOBr), in inflammatory regions are postulated to contribute to disease progression. In this study, we showed that ergothioneine (EGT), derived from an edible mushroom, inhibited MPO activity as well as the formation of 8-bromo-2'-deoxyguanosine in vitro. The HOBr scavenging effect of EGT is higher than those of ascorbic acid and glutathione. We initially observed that the administration of Coprinus comatus, an edible mushroom containing a high amount of EGT, inhibited the UV-B-induced inflammatory responses and DNA halogenation, suggesting that EGT is a promising anti-inflammatory agent from mushrooms.

Keywords

anti-inflammatory agent; ergothioneine; hypobromous acid; mushroom; myeloperoxidase.

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