2. Academic Validation
  3. Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

  • Chem Commun (Camb). 2016 Mar 18;52(22):4187-90. doi: 10.1039/c6cc00615a.
T L Harris 1,  C J Wenthur 1,  A Diego-Taboada 2,  G Mackenzie 2,  T S Corbitt 3,  K D Janda 1
Affiliations

Affiliations

  • 1 Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. [email protected].
  • 2 Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, England and Sporomex Limited, Medina House, 2 Station Avenue, Bridlington, East Yorkshire Y016 4LZ, England.
  • 3 Sporomex Limited, Medina House, 2 Station Avenue, Bridlington, East Yorkshire Y016 4LZ, England.
PMID: 26906286 DOI: 10.1039/c6cc00615a
Abstract

3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

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