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Amifampridine (Synonyms: 3,4-Diaminopyridine)

Cat. No.: HY-14946 Purity: 99.59%
Handling Instructions

Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. Amifampridine is mainly used to treat some rare muscle diseases.

For research use only. We do not sell to patients.

Amifampridine Chemical Structure

Amifampridine Chemical Structure

CAS No. : 54-96-6

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 66 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 66 In-stock
Estimated Time of Arrival: December 31
Solid
100 mg USD 60 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Amifampridine, or 3,4-diaminopyridine (3,4-DAP), is a quaternary ammonium compound that blocks presynaptic potassium channels, and subsequently prolongs the action potential and increases presynaptic calcium concentrations. Amifampridine is mainly used to treat some rare muscle diseases.

Clinical Trial
Molecular Weight

109.13

Formula

C5H7N3

CAS No.
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 38 mg/mL (348.21 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 9.1634 mL 45.8169 mL 91.6338 mL
5 mM 1.8327 mL 9.1634 mL 18.3268 mL
10 mM 0.9163 mL 4.5817 mL 9.1634 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (22.91 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.5 mg/mL (22.91 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (22.91 mM); Clear solution

*All of the co-solvents are available by MCE.
References

Purity: 99.59%

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Product Name:
Amifampridine
Cat. No.:
HY-14946
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