1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Amifampridine phosphate

Amifampridine phosphate (Synonyms: 3,4-Diaminopyridine phosphate)

Cat. No.: HY-14946A
Handling Instructions

Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research.

For research use only. We do not sell to patients.

Amifampridine phosphate Chemical Structure

Amifampridine phosphate Chemical Structure

CAS No. : 446254-47-3

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Description

Amifampridine (3,4-Diaminopyridine) phosphate is an orally active potassium channel blocker (PCB), can block presynaptic potassium channels[1]. Amifampridine phosphate can be used in Lambert-Eaton myasthenic syndrome (LEMS) research[1].

In Vivo

Amifampridine phosphate treatment (Intravenous injection; 2.5 mg/kg; once) shows 1 hour plasma half-life[2].
Amifampridine phosphate treatment (Oral administration; 10 mg/kg; once) shows plasma concentrations spike[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mice[2]
Dosage: 2.5 mg/kg
Administration: Intravenous injection; 2.5 mg/kg; once
Result: Had a plasma half-life of about 1 hour.
Animal Model: Mice[2]
Dosage: 10 mg/kg
Administration: Oral administration; 10 mg/kg; once
Result: Exhibited a rapid spike in plasma concentrations.
Molecular Weight

207.12

Formula

C5H10N3O4P

CAS No.
SMILES

NC1=C(N)C=CN=C1.O=P(O)(O)O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Amifampridine phosphate
Cat. No.:
HY-14946A
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