Lycopodium clavatum exine microcapsules enable safe oral delivery of 3,4-diaminopyridine for treatment of botulinum neurotoxin A intoxication

  • Chem Commun (Camb). 2016 Mar 18;52(22):4187-90. doi: 10.1039/c6cc00615a.
T L Harris  1 ,  C J Wenthur  1 ,  A Diego-Taboada  2 ,  G Mackenzie  2 ,  T S Corbitt  3 ,  K D Janda  1
Affiliations
  • 1. Department of Chemistry, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. [email protected].
  • 2. Department of Chemistry, University of Hull, Cottingham Road, Hull HU6 7RX, England and Sporomex Limited, Medina House, 2 Station Avenue, Bridlington, East Yorkshire Y016 4LZ, England.
  • 3. Sporomex Limited, Medina House, 2 Station Avenue, Bridlington, East Yorkshire Y016 4LZ, England.
PMID: 26906286 DOI: 10.1039/c6cc00615a
Abstract

3,4-Diaminopyridine has shown promise in reversing botulinum intoxication, but poor pharmacokinetics and a narrow therapeutic window limit its clinical utility. Thus, we developed a pH-dependent oral delivery platform using club moss spore exines. These exine microcapsules slowed 3,4-diaminopyridine absorption, limited its seizure activity, and enabled delivery of doses which prolonged mouse survival after botulism neurotoxin A intoxication.

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