2. Academic Validation
  3. Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer

Natural Compound Methyl Protodioscin Suppresses Proliferation and Inhibits Glycolysis in Pancreatic Cancer

  • Evid Based Complement Alternat Med. 2018 Mar 15:2018:7343090. doi: 10.1155/2018/7343090.
LianYu Chen 1 2,  Chien-Shan Cheng 1 2,  HuiFeng Gao 1 2,  Ling Zhan 1 2,  FengJiao Wang 1 2,  Chao Qu 1 2,  Ye Li 1 2,  Peng Wang 1 2,  Hao Chen 1 2,  ZhiQiang Meng 1 2,  LuMing Liu 1 2,  HaiFeng Chen 3,  Zhen Chen 1 2
Affiliations

Affiliations

  • 1 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China.
  • 2 Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
  • 3 School of Pharmaceutical Sciences, Xiamen University, Xiamen 361000, China.
PMID: 29736179 DOI: 10.1155/2018/7343090
Abstract

Methyl protodioscin (MPD) is one of the main bioactive components in the plant of Dioscoreaceae. MPD has been demonstrated to possess antitumor activities. However, its role in pancreatic Cancer and the underlying molecular mechanisms are poorly defined. In the present study, we demonstrated that MPD inhibited proliferation and promoted Apoptosis of pancreatic Cancer. Furthermore, our results demonstrated that MPD decreased oncogene c-Myc in protein level and resulted in concomitant reduction in glycolysis. In vivo assays with xenograft mouse model further confirmed the in vitro observations, which indicated that MPD inhibited 18FDG uptake in tumors formed by subcutaneously injection of MIA PaCa-2 cells. Collectively, our present study uncovered novel antitumor functions of MPD in pancreatic Cancer and provided the possible molecular mechanism.

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