2. Academic Validation
  3. Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

Rhomboidal Pt(II) metallacycle-based NIR-II theranostic nanoprobe for tumor diagnosis and image-guided therapy

  • Proc Natl Acad Sci U S A. 2019 Feb 5;116(6):1968-1973. doi: 10.1073/pnas.1817021116.
Yue Sun 1 2 3,  Feng Ding 1 2,  Zhixuan Zhou 3,  Chonglu Li 1 2,  Maoping Pu 4,  Yuling Xu 1 2,  Yibei Zhan 5,  Xiaoju Lu 5,  Haibing Li 6 2,  Guangfu Yang 6 2,  Yao Sun 6 2,  Peter J Stang 7
Affiliations

Affiliations

  • 1 Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China.
  • 2 International Joint Research Center for Intelligent Biosensor Technology and Health, Chemical Biology Center, College of Chemistry, Central China Normal University, 430079 Wuhan, China.
  • 3 Department of Chemistry, University of Utah, Salt Lake City, UT 84112.
  • 4 Institute of Organic Chemistry, Rheinisch-Westfälische Technische Hochschule Aachen University, 52074 Aachen, Germany.
  • 5 School of Chemistry and Chemical Engineering, Hubei Polytechnic University, Huangshi 435003, China.
  • 6 Key Laboratory of Pesticides and Chemical Biology, Ministry of Education, College of Chemistry, Central China Normal University, 430079 Wuhan, China; [email protected] [email protected] [email protected] [email protected].
  • 7 Department of Chemistry, University of Utah, Salt Lake City, UT 84112; [email protected] [email protected] [email protected] [email protected].
PMID: 30670648 DOI: 10.1073/pnas.1817021116
Abstract

Fluorescent theranostics probes at the second near-IR region (NIR-II; 1.0-1.7 µm) are in high demand for precise theranostics that minimize autofluorescence, reduce photon scattering, and improve the penetration depth. Herein, we designed and synthesized an NIR-II theranostic nanoprobe 1 that incorporates a Pt(II) metallacycle 2 and an organic molecular dye 3 into DSPE-mPEG5000 (1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-5000]). This design endows 1 with good photostability and passive targeting ability. Our studies show that 1 accurately diagnoses Cancer with high resolution and selectively delivers the Pt(II) metallacycle to tumor regions via an enhanced permeability and retention effect. In vivo studies reveal that 1 efficiently inhibits the growth of tumor with minimal side effects. At the same time, improved fluorescent imaging quality and signal-to-noise ratios are shown due to the long emission wavelengths. These studies demonstrate that 1 is a potential theranostic platform for tumor diagnosis and treatment in the NIR-II region.

Keywords

image-guided therapy; metallacycle; second near-infrared region; supramolecular coordination complexes; theranostic.

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