2. Academic Validation
  3. Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration

Asiaticoside-laden silk nanofiber hydrogels to regulate inflammation and angiogenesis for scarless skin regeneration

  • Biomater Sci. 2021 Jul 27;9(15):5227-5236. doi: 10.1039/d1bm00904d.
Lutong Liu 1,  Zhaozhao Ding 1,  Yan Yang 2,  Zhen Zhang 2,  Qiang Lu 1,  David L Kaplan 3
Affiliations

Affiliations

  • 1 National Engineering Laboratory for Modern Silk &Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215213, People's Republic of China. [email protected].
  • 2 Department of Dermatology, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China. [email protected].
  • 3 Department of Biomedical Engineering, Tufts University, Medford, Massachusetts 02155, USA.
PMID: 34190240 DOI: 10.1039/d1bm00904d
Abstract

Scarless skin regeneration remains a challenge due to the complicated microenvironment involved in wound healing. Here, the hydrophobic drug, asiaticoside (AC), was loaded inside silk nanofiber hydrogels to achieve bioactive and injectable matrices for skin regeneration. AC was dispersed in aqueous silk nanofiber hydrogels with retention of biological functions that regulated inflammatory reactions and vascularization in vitro. After implantation in full-thickness wound defects, these AC-laden hydrogel matrices achieved scarless wound repair. Inflammatory reactions and angiogenesis were regulated during inflammation and remodeling, which was responsible for wound regeneration similar to normal skin. Both in vitro and in vivo studies demonstrated promising applications of these AC-laden silk hydrogels towards scarless tissue regeneration.

Figures
Products