2. Academic Validation
  3. Two new triterpenes isolated from Maytenus guangxiensis C. Y. Cheng et W. L. Sha and their antiproliferative activities

Two new triterpenes isolated from Maytenus guangxiensis C. Y. Cheng et W. L. Sha and their antiproliferative activities

  • Nat Prod Res. 2022 Jan 11;1-7. doi: 10.1080/14786419.2021.2023870.
YuanYuan Huang 1 2,  Lu Chen 3,  Jing Yao 4,  XueGong Jia 1,  FuSheng Deng 1,  JingYa Mo 1,  JingQuan Yuan 1
Affiliations

Affiliations

  • 1 Scientific Experimental Center of Guangxi University of Chinese Medicine, Nanning, China.
  • 2 School of Chemistry and Materials, Nanning Normal University, Nanning, China.
  • 3 Guangxi Botanical Garden of Medicinal Plants, Nanning, China.
  • 4 Centre for Translational Medical Research in Integrative Chinese and Western Medicine, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China.
PMID: 35014566 DOI: 10.1080/14786419.2021.2023870
Abstract

Two new Triterpenes, 3β, 7β-dihydroxyolean-12-en-11-one (1) and 3β-O-acetyl-7β-hydroxyolean-12-en-11-one (2), along with four known Triterpenes 3β-hydroxyolean-12-en-11-one (3), β-amyrin (4), lup-20(29)-ene-1β, 3β-diol (5) and 1β, 3β-dihydroxy-urs-9(11)-12-diene (6), were isolated from the stems and leaves of Maytenus guangxiensis C. Y. Cheng et W. L. Sha. Their structures were elucidated using 1D and 2D NMR spectroscopy as well as MS and IR experiments. Compounds (3-6) were isolated from M. guangxiensis for the first time. Compounds 1-6 were evaluated for their antiproliferative activities against Eca-109, PANC-1, EJ and HeLa cell lines. The results showed that compounds 1-6 displayed a certain degree of inhibitory effects against the proliferation of various human Cancer cell lines.

Keywords

Maytenus guangxiensis; antiproliferative activities; cancer cells; triterpenes.

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