1. Academic Validation
  2. Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

Progesterone Attenuates SIRT1-Deficiency-Mediated Pre-Eclampsia

  • Biomolecules. 2022 Mar 9;12(3):422. doi: 10.3390/biom12030422.
Jiangnan Pei 1 Zhenzhen Liu 1 Chengjie Wang 1 Nan Chu 1 Lei Liu 1 Yao Tang 1 Haiyan Liu 1 Qianqian Xiang 2 Haidong Cheng 1 Mingqing Li 1 Weirong Gu 1
Affiliations

Affiliations

  • 1 Department of Obstetrics, Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China.
  • 2 Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China.
Abstract

Pre-eclampsia is a severe hypertensive disorder of pregnancy (HDP), mainly characterized by new-onset hypertension with proteinuria after 20-week gestation. Sirtuin1 (SIRT1), a class III histone deacetylase, is associated with the regulation of various pathophysiological processes, including inflammation, immune response, metabolism, and Autophagy. However, the effect of SIRT1 in the pathogenesis of pre-eclampsia remains to be elucidated. In this study, we found that the expression of SIRT1 was relatively lower in the placentas and serum samples of pre-eclampsia patients. Typical pre-eclampsia-like symptoms, such as hypertension, proteinuria, fetal growth restriction, kidney injury, and a narrow placental labyrinth layer, were observed in SIRT1 knockdown (SIRT1+/-) mice. Of note, these performances could be improved after the intraperitoneal injection of SIRT1 agonist SRT2104. More importantly, we found that the efficacy of progesterone on attenuating symptoms of PE was profoundly better than that of metformin in SIRT1+/- mice. In addition, our results suggested that progesterone can promote the invasion and inhibit the Apoptosis of trophoblasts. These data suggest that SIRT1 plays an important role in pre-eclampsia and that progesterone alleviates pre-eclampsia-like symptoms mediated by SIRT1 deficiency.

Keywords

SIRT1; SRT2104; metformin; pre-eclampsia; pre-eclampsia-like mice; progesterone.

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