2. Academic Validation
  3. Turning gray selenium into a nanoaccelerator of tissue regeneration by PEG modification

Turning gray selenium into a nanoaccelerator of tissue regeneration by PEG modification

  • Bioact Mater. 2022 Jan 2:15:131-144. doi: 10.1016/j.bioactmat.2021.12.026.
Jieqiong Cao 1,  Yibo Zhang 1,  Peiguang Zhang 1,  Zilei Zhang 1,  Bihui Zhang 1,  Yanxian Feng 2,  Zhixin Li 1,  Yiqi Yang 1,  Qilin Meng 1,  Liu He 1,  Yulin Cai 1,  Zhenyu Wang 1,  Jie Li 1,  Xue Chen 1,  Hongwei Liu 3,  An Hong 1,  Wenjie Zheng 4,  Xiaojia Chen 1 5
Affiliations

Affiliations

  • 1 Institute of Biomedicine & Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangdong Province Key Laboratory of Bioengineering Medicine, Guangdong Provincial biotechnology drug & Engineering Technology Research Center, National Engineering Research Center of Genetic Medicine, Guangzhou, China.
  • 2 School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, 529020, China.
  • 3 Department of Plastic Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, 510630, China.
  • 4 Department of Chemistry, Jinan University, Guangzhou, China.
  • 5 Guangzhou Red Cross Hospital, Jinan University, Guangzhou 510240, China.
PMID: 35386336 DOI: 10.1016/j.bioactmat.2021.12.026
Abstract

Selenium (Se) is an essential trace element involved in nearly all human physiological processes but suffers from a narrow margin between benefit and toxicity. The nanoform of selenium has been proven shown to be more bioavailable and less toxic, yet significant challenges remain regarding the efficient and feasible synthesis of biologically active nanoselenium. In addition, although nanoselenium has shown a variety of biological activities, more interesting nanoselenium features are expected. In this work, hydrosoluble nanoselenium termed Nano-Se in the zero oxidation state was synthesized between gray Se and PEG. A zebrafish screen was carried out in zebrafish larvae cocultured with Nano-Se. Excitingly, Nano-Se promoted the action of the FGFR, Wnt, and VEGF signaling pathways, which play crucial roles in tissue regeneration. As expected, Nano-Se not only achieved the regeneration of zebrafish tail fins and mouse skin but also promoted the repair of skin in diabetic mice while maintaining a profitable safe profile. In brief, the Nano-Se reported here provided an efficient and feasible method for bioactive nanoselenium synthesis and not only expanded the application of nanoselenium to regenerative medicine but also likely reinvigorated efforts for discovering more peculiarunique biofunctions of nanoselenium in a great variety of human diseases.

Keywords

Nanoselenium; PEG modification; Tissue regeneration; Zebrafish.

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