2. Academic Validation
  3. New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of Ziziphus cambodiana

New bioactive cyclopeptide alkaloids with rare terminal unit from the root bark of Ziziphus cambodiana

  • RSC Adv. 2018 May 17;8(33):18204-18215. doi: 10.1039/c7ra13050c.
Natthakaln Lomchoey 1,  Panomwan Panseeta 1 2,  Pornthip Boonsri 1,  Nuttapon Apiratikul 1,  Samran Prabpai 3,  Palangpon Kongsaeree 3,  Sunit Suksamrarn 1
Affiliations

Affiliations

  • 1 Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Srinakharinwirot University Bangkok 10110 Thailand [email protected].
  • 2 Department of Chemistry, Chulachomklao Royal Military Academy Nakornnayok 26001 Thailand.
  • 3 Department of Chemistry and Center for Excellence in Protein Structure and Function, Faculty of Science, Mahidol University Bangkok 10400 Thailand.
PMID: 35541146 DOI: 10.1039/c7ra13050c
Abstract

Six new 14-membered ring cyclopeptide Alkaloids, cambodines A-F (1-6), and two known compounds, frangufoline (7) and lotusanine B (8), were isolated from the root bark extract of Ziziphus cambodiana Pierre. Their structures and configurations were established based on 1D and 2D NMR, HRMS, ECD, and X-ray crystallographic data. Compounds 1 and 3 are rare 5(14)-type cyclopeptide Alkaloids that possess an imidazolidin-4-one ring in the terminal unit. The Cyclopeptides were tested for their in vitro antiplasmodial, antitubercular, and cytotoxic effects against three Cancer cell lines. Compound 3 showed significant antiplasmodial activity against the malarial Parasite Plasmodium falciparum, with an IC50 value of 6.09 μM.

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