2. Academic Validation
  3. Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration

Ionogels Derived from Fluorinated Ionic Liquids to Enhance Aqueous Drug Solubility for Local Drug Administration

  • Gels. 2022 Sep 16;8(9):594. doi: 10.3390/gels8090594.
Carolina Hermida-Merino 1,  David Cabaleiro 1,  Carlos Gracia-Fernández 2,  Jesus Valcarcel 3,  José Antonio Vázquez 3,  Noelia Sanz 4,  Martín Pérez-Rodríguez 1,  Maria Arenas-Moreira 5,  Dipanjan Banerjee 6 7,  Alessandro Longo 8 9,  Carmen Moya-Lopez 10,  Luis Lugo 1,  Patrice Bourson 10,  Ana B Pereiro 11,  Georges Salloum-Abou-Jaoude 12,  Iván Bravo 5,  Manuel M Piñeiro 1,  Daniel Hermida-Merino 1 6
Affiliations

Affiliations

  • 1 CINBIO, Departamento de Física Aplicada, Universidade de Vigo, Campus Lagoas-Marcosende, 36310 Vigo, Spain.
  • 2 TA Instruments Waters Chromatography, Tres Cantos, 28760 Madrid, Spain.
  • 3 Grupo de Reciclado y Valorización de Materiales Residuales (REVAL), Instituto de Investigaciones Marinas (IIM-CSIC), Eduardo Cabello 6, 36208 Vigo, Spain.
  • 4 Grupo de Bioquímica de Alimentos, Instituto de Investigaciones Marinas (IIM-CSIC), Eduardo Cabello 6, 36208 Vigo, Spain.
  • 5 Departamento de Química Física, Facultad de Farmacia, UCLM, 02071 Albacete, Spain.
  • 6 DUBBLE CRG/ESRF, CEDEX, 38043 Grenoble, France.
  • 7 Department of Chemistry, KU Leuven, Celestijnenlaan 200F, P.O. Box 2404, B-3001 Leuven, Belgium.
  • 8 ID20, ESRF, 71 Avenue des Martyrs, 38000 Grenoble, France.
  • 9 Istituto per lo Studio dei Materiali Nanostrutturati (ISMN)-CNR, UOS Palermo, Via Ugo La Malfa, 153, 90146 Palermo, Italy.
  • 10 LMOPS, Centrale Supélec, Université de Lorraine, 57000 Metz, France.
  • 11 LAQV, REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal.
  • 12 Constellium C-TEC Technology Center, Parc Economique Centr'alp, 725 rue Aristide Bergès, CS10027, 38341 Voreppe, France.
PMID: 36135306 DOI: 10.3390/gels8090594
Abstract

Gelatin is a popular biopolymer for biomedical applications due to its harmless impact with a negligible inflammatory response in the host organism. Gelatin interacts with soluble molecules in aqueous media as ionic counterparts such as ionic liquids (ILs) to be used as Cosolvents to generate the so-called Ionogels. The perfluorinated IL (FIL), 1-ethyl-3-methylpyridinium perfluorobutanesulfonate, has been selected as co-hydrosolvent for fish gelatin due to its low cytotoxicity and hydrophobicity aprotic polar structure to improve the drug aqueous solubility. A series of FIL/water emulsions with different FIL content and their corresponding shark gelatin/FIL Ionogel has been designed to enhance the drug solubility whilst retaining the mechanical structure and their nanostructure was probed by simultaneous SAXS/WAXS, FTIR and Raman spectroscopy, DSC and rheological experiments. Likewise, the FIL assisted the solubility of the antitumoural Doxorubicin whilst retaining the performing mechanical properties of the drug delivery system network for the drug storage as well as the local administration by a syringe. In addition, the different controlled release mechanisms of two different antitumoral such as Doxorubicin and Mithramycin from two different Ionogels formulations were compared to previous gelatin hydrogels which proved the key structure correlation required to attain specific therapeutic dosages.

Keywords

1-ethyl-3-methylpyridinium perfluorobutanesulfonate; drug delivery; emulsions; gelatin.

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