1. Academic Validation
  2. Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway

Sinapic Acid Alleviates Acute Pancreatitis in Association with Attenuation of Inflammation, Pyroptosis, and the AMPK/NF-κ B Signaling Pathway

  • Am J Chin Med. 2022 Oct 12;1-13. doi: 10.1142/S0192415X2250094X.
Zhi-Wei Huang 1 Peng Tan 2 Xiao-Kang Yi 1 Hao Chen 1 Bo Sun 1 Hao Shi 1 Zhi-Qiang Mou 1 Yong-Lang Cheng 1 Tong-Xi Li 1 Qiu Li 1 Wen-Guang Fu 1 2
Affiliations

Affiliations

  • 1 Department of General Surgery (Hepatopancreatobiliary Surgery), The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, P. R. China.
  • 2 Academician (Expert) Workstation of Sichuan Province, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, P. R. China.
Abstract

Among the diseases of the digestive system, the incidence of acute pancreatitis (AP) has increased. Although the AP is primarily self-limited, mortality remains high when it progressed to severe acute pancreatitis (SAP). Despite significant advances in new drug development, treatments for AP are not ideal. Here, we discovered a novel hydroxycinnamic acid, sinapic acid (SA), which is widely distributed in Plants and is an effective treatment for AP. Using in vitro and in vivo models, we demonstrated that pretreatment with SA ameliorated cerulein-induced pancreatic damage and inflammation and inhibited the activation of Caspase-1 and Caspase-11, which mediate Pyroptosis of pancreatic acinar cells during AP. These effects may occur through the inhibition of AMPK phosphorylation and downregulation of NF-κB. Our findings demonstrate the therapeutic effects and reveal the underlying mechanisms of SA, which warrants its further study as an effective treatment for AP.

Keywords

Acute Pancreatitis; Herbal Medicine; Hydroxycinnamic Acid; Inflammation; Pyroptosis; Sinapic Acid.

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