2. Academic Validation
  3. Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight

Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight

  • Naunyn Schmiedebergs Arch Pharmacol. 2023 Feb;396(2):229-238. doi: 10.1007/s00210-022-02302-7.
Champa Keeya Tudu 1,  Anustup Bandyopadhyay 1,  Manoj Kumar 2,  Radha 3,  Tuyelee Das 1,  Samapika Nandy 1,  Mimosa Ghorai 1,  Abilash Valsala Gopalakrishnan 4,  Jarosław Proćków 5,  Abhijit Dey 6
Affiliations

Affiliations

  • 1 Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, -700073, West Bengal, India.
  • 2 Chemical and Biochemical Processing Division, ICAR-Central Institute for Research On Cotton Technology, Mumbai, 400019, Maharashtra, India.
  • 3 School of Biological and Environmental Sciences, Shoolini University of Biotechnology and Management Sciences, Solan, 173229, Himachal Pradesh, India.
  • 4 Department of Biomedical Sciences, School of Biosciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India.
  • 5 Department of Plant Biology, Institute of Environmental Biology, Wrocław University of Environmental and Life Sciences, Kożuchowska 5b, 51-631, Wrocław, Poland. [email protected].
  • 6 Department of Life Sciences, Presidency University, 86/1 College Street, Kolkata, -700073, West Bengal, India. [email protected].
PMID: 36251044 DOI: 10.1007/s00210-022-02302-7
Abstract

Cryptolepine (1,5-methyl-10H-indolo[3,2-b]quinoline), an indoloquinoline alkaloid, found in the roots of Cryptolepis sanguinolenta (Lindl.) Schltr (family: Periplocaceae), is associated with the suppression of Cancer and protozoal infections. Cryptolepine also exhibits anti-bacterial, anti-fungal, anti-hyperglycemic, antidiabetic, anti-inflammatory, anti-hypotensive, antipyretic, and antimuscarinic properties. This review of the latest research data can be exploited to create a basis for the discovery of new cryptolepine-based drugs and their analogues in the near future. PubMed, Scopus, and Google Scholar databases were searched to select and collect data from the existing literature on cryptolepine and their pharmacological properties. Several in vitro studies have demonstrated the potential of cryptolepine A as an Anticancer and antimalarial molecule, which is achieved through inhibiting DNA synthesis and Topoisomerase II. This review summarizes the recent developments of cryptolepine pharmacological properties and functional mechanisms, providing information for future research on this natural product.

Keywords

Anti-inflammatory; Antimalarial; Antitumor; Cryptolepine; Cryptolepis sanguinolenta; Hepatoprotective; Pharmacology.

Figures
Products