2. Academic Validation
  3. Anti-inflammatory and analgesic effect of Forsythiaside B on complete Freund's adjuvant-induced inflammatory pain in mice

Anti-inflammatory and analgesic effect of Forsythiaside B on complete Freund's adjuvant-induced inflammatory pain in mice

  • Biochem Biophys Res Commun. 2023 Feb 19:645:55-60. doi: 10.1016/j.bbrc.2023.01.036.
Yu-Ting Wang 1,  Kai Lu 1,  Dan-Dan Yao 1,  Shu-Xia Zhang 1,  Gang Chen 2
Affiliations

Affiliations

  • 1 Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China.
  • 2 Department of Anesthesiology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Electronic address: [email protected].
PMID: 36680937 DOI: 10.1016/j.bbrc.2023.01.036
Abstract

Chronic pain is frequently reported in clinical practice. Therefore, it is important to identify effective therapy to relieve pain. In this work, we selected Forsythoside B (FB), a phenylethanoid glycoside isolated from Forsythia suspensa (Thunb.) Vahl, to evaluate its effect in modulating inflammatory pain induced by complete Freund's Adjuvant (CFA) and the involved mechanisms. We discovered that FB could attenuate inflammatory pain triggered by CFA injection and exert anti-anxiety effects. In detail, proinflammatory cytokines, consisting of IL-6 and TNF-α, were decreased after FB administration in the CFA-injected mice. Furthermore, the FB application ameliorated the activation of ionized calcium-binding adaptor molecule 1 (Iba-1) and glial fibrillary acidic protein (GFAP), the microglia and astrocytes markers respectively. Therefore, our findings indicate that FB could be a promising treatment for chronic inflammatory pain.

Keywords

Complete Freund's adjuvant; Forsythiaside B; Inflammation pain; Proinflammatory cytokines.

Figures
Products
Inhibitors & Agonists
Other Products