2. Academic Validation
  3. Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria

Cancer cells reprogram to metastatic state through the acquisition of platelet mitochondria

  • Cell Rep. 2023 Sep 26;42(9):113147. doi: 10.1016/j.celrep.2023.113147.
Wenkan Zhang 1,  Hao Zhou 1,  Hengyuan Li 1,  Haochen Mou 1,  Eloy Yinwang 1,  Yucheng Xue 1,  Shengdong Wang 1,  Yongxing Zhang 1,  Zenan Wang 1,  Tao Chen 1,  Hangxiang Sun 1,  Fangqian Wang 1,  Jiahao Zhang 1,  Xupeng Chai 1,  Shixin Chen 1,  Binghao Li 1,  Changqing Zhang 2,  Junjie Gao 3,  Zhaoming Ye 4
Affiliations

Affiliations

  • 1 Department of Orthopedic Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Orthopedics Research Institute of Zhejiang University, Hangzhou, Zhejiang, China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, China.
  • 2 Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address: [email protected].
  • 3 Department of Orthopaedics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China. Electronic address: [email protected].
  • 4 Department of Orthopedics, Musculoskeletal Tumor Center, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou 310009, People's Republic of China; Institute of Orthopedic Research, Zhejiang University, Hangzhou 310009, People's Republic of China; Key Laboratory of Motor System Disease Research and Precision Therapy of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China. Electronic address: [email protected].
PMID: 37756158 DOI: 10.1016/j.celrep.2023.113147
Abstract

Metastasis is the major cause of Cancer deaths, and Cancer cells evolve to adapt to various tumor microenvironments, which hinders the treatment of tumor metastasis. Platelets play critical roles in tumor development, especially during metastasis. Here, we elucidate the role of platelet mitochondria in tumor metastasis. Cancer cells are reprogrammed to a metastatic state through the acquisition of platelet mitochondria via the PINK1/Parkin-Mfn2 pathway. Furthermore, platelet mitochondria regulate the GSH/GSSG ratio and Reactive Oxygen Species (ROS) in Cancer cells to promote lung metastasis of osteosarcoma. Impairing platelet mitochondrial function has proven to be an efficient approach to impair metastasis, providing a direction for osteosarcoma therapy. Our findings demonstrate mitochondrial transfer between platelets and Cancer cells and suggest a role for platelet mitochondria in tumor metastasis.

Keywords

CP: Cancer; CP: Cell biology; glutathione; metabolic reprogram; mitochondria transfer; osteosarcoma metastasis; oxidative stress; platelets.

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