2. Academic Validation
  3. Talaesthanes A-C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21

Talaesthanes A-C, three new meroterpenoids from the endophytic fungus Talaromyces primulinus H21

  • Fitoterapia. 2024 Sep:177:106085. doi: 10.1016/j.fitote.2024.106085.
Jia-Qian Chen 1,  Shen Li 2,  Run-Zhu Fan 1,  Zhang-Hua Sun 3,  Xin-Ying Zhu 1,  Ai-Ping Yin 4,  Gui-Hua Tang 5,  Sheng Yin 1
Affiliations

Affiliations

  • 1 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
  • 2 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Clinical Trial Center, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen, China.
  • 3 Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, China.
  • 4 Department of Clinical Laboratory, The Third People's Hospital of Dongguan, Dongguan 523326, China.
  • 5 School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. Electronic address: [email protected].
PMID: 38901806 DOI: 10.1016/j.fitote.2024.106085
Abstract

Three new meroterpenoids (1-3) and ten known ones (4-13) were obtained from the endophytic fungus Talaromyces primulinus H21 isolated from the plant of Euphorbia sikkimensis. Their structures including their absolute configurations were elucidated by extensive analysis of spectroscopic data such as HR-ESI-MS, 1D/2D NMR, and X-ray diffraction of single crystal together with comparison of experimental ECD with calculated ECD. All compounds were examined for their inhibitory effects on nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 cells, and compounds 3, 9, 12, and 13 exhibited certain inhibition on NO production, with IC50 values of 27.19, 41.55, 25.23, and 24.71 μM, respectively.

Keywords

Anti-inflammatory activity; Endophytic fungus; Meroterpenoids; Talaromyces primulinus.

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